Relationship betweeen the amount and location of macrophages and clinical outcome: subanalysis of the CLIMA-study
| Autor: | Laura Gatto, Eloisa Arbustini, Alberto Boi, Filippo Crea, Fernando Alfonso, Vito Ramazzotti, Franco Fabbiocchi, Corrado Tamburino, Enrico Romagnoli, Flavio Giuseppe Biccirè, Mario Albertucci, Francesco Burzotta, Nevio Taglieri, Giulia Paoletti, Alessio La Manna, Simone Budassi, Giuseppe Calligaris, Giovanni Ruscica, Yukio Ozaki, Valeria Marco, Francesco Prati, Massimo Fineschi, Francesco Versaci, Rocco Vergallo |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
medicine.medical_specialty
Coronary Artery Disease Outcomes medicine.disease_cause Percutaneous Coronary Intervention Predictive Value of Tests Risk Factors Diabetes mellitus Internal medicine Medicine Humans Myocardial infarction Vulnerable plaque Ejection fraction Optical coherence tomography business.industry Proportional hazards model Macrophages Fibrous cap medicine.disease Coronary Vessels Plaque Atherosclerotic medicine.anatomical_structure Treatment Outcome Settore MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE Cardiology Cardiology and Cardiovascular Medicine business Tomography Optical Coherence Kidney disease Artery |
| Popis: | BACKGROUND The ability of optical coherence tomography (OCT) to recognize intraplaque macrophage infiltration is now well acknowledged. This post-hoc analysis of the CLIMA study aimed to address the clinical impact of the circumferential extension of OCT-defined macrophages and their location at one year follow-up. METHODS The multicentre CLIMA study enrolled 1003 patients undergoing OCT evaluation of the untreated proximal left anterior descending (LAD) coronary artery. Measurements of circumferential extension of macrophages and measurements of the distance from intima-lumen contour to macrophages string were performed at the plaque cross-section judged as containing the greatest amount of macrophages. The main study endpoint was a composite of cardiac death, myocardial infarction (MI) and/or target vessel revascularization (TVR). RESULTS Patients with large macrophage arc (p = 0.001) and superficial macrophage arc (p |
| Databáze: | OpenAIRE |
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