Association between suicidal behaviour and impaired glucose metabolism in depressive disorders
| Autor: | Hannu Kautiainen, Esa Leppänen, Pekka Mäntyselkä, Mauno Vanhala, Hannu Koponen |
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| Přispěvatelé: | Clinicum, Department of Psychiatry, Department of General Practice and Primary Health Care, HUS Psychiatry |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
Personality Inventory Poison control Suicide Attempted KEY COMPONENT Suicidality Triglyceride 3124 Neurology and psychiatry ACTIVATION NATIONAL-COMORBIDITY-SURVEY Suicide attempt Suicidal ideation Depression (differential diagnoses) Finland Metabolic Syndrome RISK INSULIN-RESISTANCE Depression PSYCHIATRIC-DISORDERS Middle Aged Antidepressive Agents 3. Good health Psychiatry and Mental health Cholesterol Suicidal behaviour Major depressive disorder Female medicine.symptom Research Article Adult medicine.medical_specialty Ideation Suicidal Ideation Insulin resistance INFLAMMATION Internal medicine MENTAL-DISORDERS medicine Humans Psychiatry SERUM-CHOLESTEROL Aged Depressive Disorder Major business.industry Quantitative insulin sensitivity check index CYTOKINES Beck Depression Inventory medicine.disease Glucose Metabolic syndrome business Epidemiologic Methods |
| Zdroj: | BMC Psychiatry |
| Popis: | Background: Disturbances in lipid metabolism have been linked to suicidal behaviour, but little is known about the association between suicide risk and abnormal glucose metabolism in depression. Hyperglycaemia and hyperinsulinaemia may increase the risk of depression and also the risk for suicide, we therefore studied associations between suicidal behaviour and disturbances in glucose metabolism in depressive patients who had been referred to depression nurse case managers. Methods: Patients aged 35 years and older (N = 448, mean age 51 years) who were experiencing a new depressive episode, who were referred to depression nurse case managers in 2008-2009 and who scored = 10 on the Beck Depression Inventory were enrolled in this study. The study was conducted in municipalities within the Central Finland Hospital District (catchment area of 274 000 inhabitants) as part of the Finnish Depression and Metabolic Syndrome in Adults study. The patients' psychiatric diagnoses and suicidal behaviour were confirmed by the Mini-International Neuropsychiatric Interview. Blood samples, for glucose and lipid determinations, were drawn from participants after 12 h of fasting, which was followed by a 2-hour oral glucose tolerance test (OGTT) when blood was drawn at 0 and 2 h. Insulin resistance was measured by the Quantitative Insulin Sensitivity Check Index (QUICKI) method.' Results: Suicidal ideation (49 %) and previous suicide attempts (16 %) were common in patients with major depressive disorder or dysthymia. Patients with depression and suicidal behaviour had higher blood glucose concentrations at baseline and at 2 hours in the OGTT. Glucose levels associated positively with the prevalence of suicidal behaviour, and the linearity was significant at baseline (p for linearity: 0.012, adjusted for age and sex) and for 2-hour OGTT glucose (p for linearity: 0.004, adjusted for age and sex). QUICKI levels associated with suicidal behavior (p for linearity across tertiles of QUICKI: 0.026). Total and LDL cholesterol and triglyceride levels were also higher in those patients with suicidal behaviour. Multivariate analysis revealed that blood glucose levels, BDI scores and antidepressive medications associated with suicidal behaviour. Conclusion: Insulin resistance and disturbances in glucose and lipid metabolism may be more common in middle-aged depressive patients with suicidal behaviour. |
| Databáze: | OpenAIRE |
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