Antidiabetic Activity of Sargassum hystrix Extracts in Streptozotocin-Induced Diabetic Rats
| Autor: | Ustadi, Amir Husni, Theodora Linggaryati Gotama |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Necrosis chemistry.chemical_compound 0404 agricultural biotechnology Internal medicine Diabetes mellitus medicine Nutrition and Dietetics medicine.diagnostic_test Cholesterol business.industry Histology Articles 04 agricultural and veterinary sciences Streptozotocin medicine.disease 040401 food science polyphenol lipid profile pancreatic necrosis Sargassum hystrix medicine.anatomical_structure Endocrinology Postprandial chemistry antihyperglycemia medicine.symptom Pancreas Lipid profile business Food Science medicine.drug |
| Zdroj: | Preventive Nutrition and Food Science |
| ISSN: | 2287-8602 2287-1098 |
| DOI: | 10.3746/pnf.2018.23.3.189 |
| Popis: | The objective of this research was to determine the potential effects of Sargassum hystrix extracts (SHE) on the glucose levels, lipid profile, and pancreas of streptozotocin (STZ)-induced diabetic rats. SHE at 200, 300, and 400 mg/kg was administered orally to STZ-induced diabetic rats once daily for 15 days. Glucose levels, lipid profile, and weight of rats were measured in the normal state and on the 15th day. The histology of the pancreas was observed on the 15th day. The results showed that the preprandial and postprandial glucose levels in the group treated with SHE at 300 mg/kg were significantly reduced compared with those of the diabetes group. Additionally, the levels of triglycerides and cholesterol in the 300 mg/kg SHE group were significantly different from those in the diabetes group. However, the levels of high-density lipoprotein cholesterol and low-density lipoprotein cholesterol across the treatment groups did not have significant differences. Necrosis was found in all STZ-induced rats. SHE at a dose of 300 mg/kg had the best capability to lower the levels of preprandial and postprandial glucose and to prevent necrosis in diabetic rats. |
| Databáze: | OpenAIRE |
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