Fetal subependymal giant cell astrocytoma: A case report and review of the literature
| Autor: | Ploutarchos Karydakis, Ioannis Nikas, Dimitrios Giakoumettis, Marios Themistocleous, George Sfakianos, Aikaterini Karagianni |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Everolimus Subependymal giant cell astrocytoma business.industry medicine.medical_treatment Tuberous sclerosis Gestational age Case Report medicine.disease Congenital In utero diagnosis In utero Giant cell medicine Subependymal zone Surgery Neurology (clinical) Radiology business Craniotomy medicine.drug |
| Zdroj: | Surgical Neurology International |
| ISSN: | 2152-7806 2229-5097 |
| Popis: | Background: Subependymal giant cell astrocytomas (SEGAs) appear approximately in 10% of patients with tuberous sclerosis. These tumors are most commonly diagnosed in childhood and adolescence, with in utero diagnosed SEGAs being an extremely rare entity. Case Description: We present the case of a congenital SEGA detected in an antenatal ultrasound and further investigated with fetal magnetic resonance imaging (MRI) scans at 22 and 32 weeks of gestational age. At 9 days of age, the child underwent craniotomy and partial excision of the tumor, followed by a second more extensive operation 13 days later. The patient was subsequently administered mammalian target of rapamycin inhibitor (everolimus). Conclusion: In the latest follow-up MRI, at the age of two, the SEGA remained unchanged. Management of these tumors in neonates is challenging, mainly due to high morbidity and mortality of surgical treatment in these ages. |
| Databáze: | OpenAIRE |
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