Carotid chemoreceptor response to increases in CO2 output
| Autor: | S.J.G. Semple, Brenda A. Cross, Douglas R. Corfield, Kathryn D. Howells, R.P. Stidwill, G.B. Newman |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Pulmonary and Respiratory Medicine
Chemoreceptor Physiology Carotid chemoreceptor Animal science medicine Carnivora Animals Respiratory system Carotid Body CATS biology Chemistry Respiration Fissipedia Carbon Dioxide Hydrogen-Ion Concentration biology.organism_classification Chemoreceptor Cells Carotid Arteries medicine.anatomical_structure Control of respiration Anesthesia Cats Carotid body circulatory and respiratory physiology |
| Zdroj: | Respiration Physiology. 81:99-115 |
| ISSN: | 0034-5687 |
| DOI: | 10.1016/0034-5687(90)90073-8 |
| Popis: | The effect on carotid chemoreceptor activity of alterations in PaCO2 oscillations produced by venous CO2 loading via the small intestines was studied in anaesthetised cats, which were paralysed and ventilated at constant frequency. Changes in PaCO2 oscillations were assessed from continuously recorded oscillations of arterial pH. Chemoreceptor activity was averaged over 20-50 pH cycles to determine the amplitude (csnd ampl) and mean level (csnd mean) of the respiratory fluctuation in discharge frequency during control and CO2 loaded periods. Two groups of 5 cats were studied. In both groups, the amplitude of the PaCO2 oscillations increased by an overall average of 74.5% (standard error, SE = 9.2) with minimal change in mean PaCO2 (average increase 0.7 mm Hg), in response to an increase in VCO2 of 77.5% (SE = 7.4). When isoxia was maintained (Group 1) csnd ampl increased by 51.3% (SE = 11.1) and csnd mean by 17.3% (SE = 7.8). In Group 2, PaO2 rose by 16.7 mm Hg (SE = 1.5) during CO2 loading and both csnd ampl and csnd mean decreased by 7.4% (SE = 9.3) and 2.3% (SE = 13.3) respectively. The results demonstrate a sensitivity of chemoreceptors to changes in VCO2 which is influenced by small changes in PaO2. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|