Morphogenesis of the mitochondrial alterations in muscle diseases
| Autor: | Vinod Sahgal, Harvinder Singh, George Muschler, A. Shah, Venka Subramani |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Morphogenesis
chemistry.chemical_element Venom Vacuole Oxidative phosphorylation Mitochondrion Calcium Biology Myofibrils Animals Humans Respiratory system skin and connective tissue diseases Uncoupling Agents Vesicle Muscles Rats Inbred Strains Intracellular Membranes Neuromuscular Diseases Crotoxin Cell biology Mitochondria Muscle Rats Disease Models Animal Microscopy Electron Neurology chemistry sense organs Neurology (clinical) 2 4-Dinitrophenol Mitochondrial Swelling Dinitrophenols |
| Zdroj: | Journal of the neurological sciences. 55(1) |
| ISSN: | 0022-510X |
| Popis: | In this paper we present sequential morphologic changes produced in rat muscle mitochondria. Respiratory toxins such as crotoxin (rattle-snake venom) and 2,4-dinitrophenol (DNP-an uncoupler of oxidative phosphorylation) were injected in rat quadriceps muscle and the mitochondrial aterations were studied at various time intervals. The series of mitochondrial changes consisted of rounding and swelling of mitochondria, unfolding of the cristae as straight lines, formation of the concentric rings, appearance of paracrystalline inclusions, formation of multiple vesicles and finally vacuole formation. These changes were comparable to the range of mitochondrial alterations seen in the human material examined. Similarity of the timerelated mitochondrial changes in the rat to the spectrum of changes observed in human muscle biopsies suggests that the mitochondrial alteration in the human muscle disorders is a stepwise process in which respiratory alterations and calcium ion may play a role. |
| Databáze: | OpenAIRE |
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