Mitral valve prolapse morphofunctional features by cardiovascular magnetic resonance: more than just a valvular disease
| Autor: | Leticia Fernández Friera, Valentin Fuster, Javier Sanz, Angélica Romero Daza, Nicolas Maneiro, Jose M. Larrañaga-Moreira, Ana Guijarro Contreras, Patricia Pardo, Aalap Chokshi, Borja Ibanez, Jorge Solis |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Magnetic Resonance Spectroscopy Diastole Muscle hypertrophy Predictive Value of Tests Internal medicine Mitral valve medicine Mitral valve prolapse Humans Diseases of the circulatory (Cardiovascular) system Radiology Nuclear Medicine and imaging cardiovascular diseases Mitral regurgitation Ejection fraction Radiological and Ultrasound Technology medicine.diagnostic_test business.industry Research Mitral Valve Insufficiency Magnetic resonance imaging Papillary Muscles Myocardial strain medicine.disease medicine.anatomical_structure Ventricle RC666-701 Cardiology cardiovascular system Female Cardiovascular magnetic resonance Cardiology and Cardiovascular Medicine business |
| Zdroj: | Journal of Cardiovascular Magnetic Resonance, Vol 23, Iss 1, Pp 1-14 (2021) Journal of Cardiovascular Magnetic Resonance |
| Popis: | IntroductionMitral valve (MV) prolapse (MVP) is a primary valvular abnormality. We hypothesized that additionally there are concomitant abnormalities of the left ventricle (LV) and MV apparatus in this entity even in the absence of significant mitral regurgitation (MR).ObjectiveTo characterize MV and LV anatomic and functional features in MVP with preserved LV ejection fraction, with and without significant MR, using cardiovascular magnetic resonance (CMR).MethodsConsecutive MVP patients (n = 80, mean 52 years, 37% males) with preserved LV ejection fraction, and 44 controls (46 years, 52% males) by CMR were included, as well as 13 additional patients with “borderline” MVP. From cine images we quantified LV volumes, MV and LV anatomic measurements (including angle between diastolic and systolic annular planes, annular displacement, and basal inferolateral hypertrophy) and, using feature tracking, longitudinal and circumferential peak systolic strains.ResultsSignificant MR was found in 46 (56%) MVP patients. Compared with controls, MVP patients had LV enlargement, basal inferolateral hypertrophy, higher posterior annular excursion, and reduced shortening of the papillary muscles. LV basal strains were significantly increased, particularly in several basal segments. These differences remained significant in patients without significant MR, and many persisted in “borderline” MVP.ConclusionsIn patients with MVP and preserved LV ejection fraction there is LV dilatation, basal inferolateral hypertrophy, exaggerated posterior annular displacement and increased basal deformation, even in the absence of significant MR or overt MVP. These findings suggest that MVP is a disease not only of the MV but also of the adjacent myocardium. |
| Databáze: | OpenAIRE |
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