Effects of Sucrose Palmitate on the Physico-Chemical and Mucoadhesive Properties of Buccal Films

Autor: Romána Zelkó, Géza Regdon, Zoltán Aigner, Klára Pintye-Hódi, András Kelemen, István Sebe, Bálint Katona, Katalin Kristó, Szilvia Módra
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Sucrose
Materials science
Polymers
buccal film
Drug Compounding
mucoadhesive work
sucrose-palmitate
Pharmaceutical Science
02 engineering and technology
030226 pharmacology & pharmacy
Article
Analytical Chemistry
Contact angle
lcsh:QD241-441
03 medical and health sciences
Drug Delivery Systems
Hypromellose Derivatives
0302 clinical medicine
X-Ray Diffraction
lcsh:Organic chemistry
Buccal use
Adhesives
Tensile Strength
Drug Discovery
Ultimate tensile strength
Mucoadhesion
Humans
Physical and Theoretical Chemistry
Cellulose
Positron annihilation
Organic Chemistry
Mouth Mucosa
Adhesiveness
Administration
Buccal
Sucrose Palmitate
Buccal administration
Permeation
021001 nanoscience & nanotechnology
Drug Liberation
Spectrophotometry
Chemistry (miscellaneous)
Molecular Medicine
Stress
Mechanical
0210 nano-technology
Software
mucoadhesion
Nuclear chemistry
Zdroj: Molecules, Vol 25, Iss 5248, p 5248 (2020)
Molecules
Volume 25
Issue 22
ISSN: 1420-3049
Popis: In our current research, sucrose palmitate (SP) was applied as a possible permeation enhancer for buccal use. This route of administration is a novelty as there is no literature on the use of SP in buccal mucoadhesive films. Films containing SP were prepared at different temperatures, with different concentrations of SP and different lengths of hydroxypropyl methylcellulose (HPMC) chains. The mechanical, structural, and in vitro mucoadhesive properties of films containing SP were investigated. Tensile strength and mucoadhesive force were measured with a device and software developed in our Institute. Positron annihilation lifetime spectroscopy (PALS) and X-ray powder diffractometry (XRPD) were applied for the structure analysis of the films. Mucoadhesive work was calculated in two ways: from the measured contact angle and compared with direct mucoadhesive work, which measured mucoadhesive force, which is direct mucoadhesion work. These results correlate linearly with a correlation coefficient of 0.98. It is also novel because it is a new method for the determination of mucoadhesive work.
Databáze: OpenAIRE
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