Quantitative evaluation of internal marks made using MRgFUS as seen on MRI, CT, US, and digital color images – A pilot study
| Autor: | Charles A. Pelizzari, Xiaobing Fan, Christopher M. Straus, Gregory S. Karczmar, Ari Partanen, Elizabeth Hipp, Sham Sokka, James Vosicky |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Diagnostic Imaging
medicine.medical_specialty Hot Temperature Biopsy medicine.medical_treatment Biophysics Color General Physics and Astronomy Pilot Projects Computed tomography Article Radiation Ionizing medicine Medical imaging Animals Edema Radiology Nuclear Medicine and imaging Muscle Skeletal Ultrasonography Radiotherapy procedures medicine.diagnostic_test business.industry Reproducibility of Results Magnetic resonance imaging General Medicine Magnetic Resonance Imaging High-intensity focused ultrasound Rabbits Radiology Signal intensity Tomography X-Ray Computed business |
| Zdroj: | Physica Medica. 30:941-946 |
| ISSN: | 1120-1797 |
| DOI: | 10.1016/j.ejmp.2014.04.007 |
| Popis: | This pilot study compared the detectability of internal thermal marks produced with MRI-guided focused ultrasound (MRgFUS) on MRI, computed tomography (CT), ultrasonography (US), and color images from digital scanning. Internal marks made using MRgFUS could potentially guide surgical, biopsy or radiotherapy procedures. New Zealand White rabbits (n = 6) thigh muscle were marked using a Philips MRgFUS system. Before and after sonications, rabbits were imaged using T1- and T2-weighted MRI. Then rabbits were sacrificed and imaging was performed using CT and US. After surgical excision specimens were scanned for color conspicuity analysis. Images were read by a radiologist and quantitative analysis of signal intensity was calculated for marks and normal muscle. Of a total of 19 excised marks, approximately 79%, 63%, and 62% were visible on MRI, CT, and US, respectively. The average maximum temperature elevation in the marks during MRgFUS was 39.7 ± 10.1 °C, and average dose diameter (i.e., the diameter of the area that achieved a thermal dose greater than 240 cumulative equivalent minutes at 43 °C) of the mark at the focal plane was 7.3 ± 2.1 mm. On MRI the average normalized signal intensities were significantly higher in marks compared to normal muscle (p < 0.05). On CT, the marked regions were approximately 10 HU lower than normal muscle (p < 0.05). The results demonstrate that MRgFUS can be used to create internal marks that are visible on MRI, CT and US. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect