Use of Angiotensin-Converting Enzyme Inhibitors and Cardiovascular Outcomes Following Primary Vascular Surgery
| Autor: | Leif Panduro Jensen, Henrik Nielsen, Annette Høgh, Søren Paaske Johnsen, Jes S. Lindholt |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Reoperation medicine.medical_specialty Time Factors Denmark Population Myocardial Infarction Angiotensin-Converting Enzyme Inhibitors Peripheral Arterial Disease Risk Factors Internal medicine Humans Medicine Registries Propensity Score education Aged Proportional Hazards Models Aged 80 and over education.field_of_study biology business.industry Proportional hazards model Hazard ratio Angiotensin-converting enzyme General Medicine Middle Aged Vascular surgery Confidence interval Surgery Treatment Outcome Cardiovascular Diseases Multivariate Analysis ACE inhibitor Propensity score matching biology.protein Female Cardiology and Cardiovascular Medicine business Vascular Surgical Procedures Follow-Up Studies medicine.drug |
| Zdroj: | Høgh, A, Lindholt, J S, Nielsen, H, Jensen, L P & Johnsen, S P 2012, ' Use of Angiotensin-Converting Enzyme Inhibitors and Cardiovascular Outcomes Following Primary Vascular Surgery : A Nationwide Propensity Score Matched Follow-up Study ', Vascular and Endovascular Surgery, vol. 46, no. 7, pp. 515-23 . https://doi.org/10.1177/1538574412455229 Høgh, A L, Lindholt, J S, Nielsen, H, Jensen, L P & Johnsen, S P 2012, ' Use of angiotensin-converting enzyme inhibitors and cardiovascular outcomes following primary vascular surgery : a nationwide propensity score matched follow-up study ', Italian Journal of Vascular and Endovascular Surgery, vol. 46, no. 7, pp. 515-23 . https://doi.org/10.1177/1538574412455229 |
| ISSN: | 1938-9116 1538-5744 |
| DOI: | 10.1177/1538574412455229 |
| Popis: | Objective: To examine the association between angiotensin-converting enzyme (ACE) inhibitor use and clinical outcome after primary vascular reconstruction in a population-based follow-up study. Methods: All Danish patients undergoing primary vascular surgical reconstruction between 1996 and 2007 were included. For each ACE user up to 5 nonuser was identified using propensity score matching followed by Cox regression. All drugs were included as time-dependent variables. Results: Totally 17 495 matched patients with a median follow-up period of 582 days were included. All-cause mortality was 20.4% for ACE users and 24.9% for nonusers (adjusted hazard ratio [adj HR] 0.88, 95% confidence interval [CI] 0.81-0.96). The cumulative risk of myocardial infarction was 6.2% for ACE users and 4.7% for nonusers (adj HR 1.20, 95%CI 1.03-1.39). Cumulative risk of new vascular surgery was 24.0% for ACE users and 23.1% for nonusers (adj HR 1.21, 95% CI 1.13-1.30). No differences were seen concerning stroke and major amputation. Conclusion: The ACE use was associated with lower all-cause mortality but also an increased long-term risk of recurrent vascular reconstruction. |
| Databáze: | OpenAIRE |
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