Aminoglutethimide (Elipten-Ciba) as an Inhibitor of Adrenal Steroidogenesis: Mechanism of Action and Therapeutic Trial
| Autor: | M N Cohen, R Cash, A J Brough, P S Satoh |
|---|---|
| Rok vydání: | 1967 |
| Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry Enzyme Therapy Lyases Breast Neoplasms Adrenocorticotropic hormone Biochemistry Steroid chemistry.chemical_compound Endocrinology Adrenocorticotropic Hormone Adrenal Cortex Hormones Internal medicine Adrenal Glands medicine Animals Humans Neoplasm Metastasis Child Cushing Syndrome Clinical Trials as Topic Chemistry Cholesterol Cholesterol side-chain cleavage enzyme Biochemistry (medical) Middle Aged Aminoglutethimide Enzymes Rats Steroid hormone Epilepsy Absence Mechanism of action Pregnenolone Anticonvulsants Female medicine.symptom Hormone medicine.drug |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 27:1239-1248 |
| ISSN: | 1945-7197 0021-972X |
| Popis: | Aminoglutethimide (Elipten-Ciba) has been shown to be a potent inhibitor of adrenal steroidogenesis as well as thyroidal organification of iodine. Administration of the drug to animals and humans resulted in distinct histologic changes of the adrenals, including cellular hypertrophy, cytoplasmic vacuolation, and excessive accumulation of lipid. It is suggested that these findings may be similar to that described by Prader as lipoid adrenal hyperplasia. Assays for the adrenal cholesterol side chain cleaving enzyme system (desmolase complex) were performed. The presence of Elipten in the incubation mixture produced inhibition of the enzymatic conversion of cholesterol to Δ5-pregnenolone. This early pathway is required for the biosynthesis of all steroid hormones. The drug was administered to 2 patients in a therapeutic attempt to inhibit steroid synthesis, with apparent success. Elipten inhibits enzymatic cleavage of the cholesterol side chain and may be a valuable drug in the treatment of diseases... |
| Databáze: | OpenAIRE |
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