Relationship between hyperglycemia, antioxidant capacity and some enzymatic and non-enzymatic antioxidants in African patients with type 2 diabetes
| Autor: | Francine Tankeu Nzufo, Vicky Jocelyne Ama Moor, Eugene Sobngwi, Bruno Moukette Moukette, Borgia Legrand Njinkio Nono, Prosper Cabral Biapa Nya, Gustave Simo, Jérôme Antony Tatangmo, Constant Anatole Pieme |
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| Jazyk: | angličtina |
| Předmět: |
Blood Glucose
Male 0301 basic medicine lcsh:Medicine Type 2 diabetes medicine.disease_cause Antioxidants Lipid peroxidation chemistry.chemical_compound 0302 clinical medicine Malondialdehyde Medicine Cameroon lcsh:QH301-705.5 Medicine(all) biology Fasting General Medicine Middle Aged Catalase Glutathione 030220 oncology & carcinogenesis Female Research Article Adult medicine.medical_specialty Nitric Oxide General Biochemistry Genetics and Molecular Biology Nitric oxide 03 medical and health sciences Diabetes mellitus Internal medicine Humans lcsh:Science (General) Aged Glycated Hemoglobin Superoxide Dismutase business.industry Biochemistry Genetics and Molecular Biology(all) lcsh:R Total Antioxidant Capacity medicine.disease 030104 developmental biology Endocrinology Diabetes Mellitus Type 2 chemistry lcsh:Biology (General) Oxidative stress Hyperglycemia biology.protein Lipid Peroxidation business Biomarkers lcsh:Q1-390 |
| Zdroj: | BMC Research Notes, Vol 10, Iss 1, Pp 1-7 (2017) BMC Research Notes |
| ISSN: | 1756-0500 |
| DOI: | 10.1186/s13104-017-2463-6 |
| Popis: | Background and purpose Studies demonstrate that free radicals are involved in the pathogenesis of diabetic complications. The aim of this study was to determine the implication of total antioxidant capacity (TAC) and some enzymatic and non-enzymatic antioxidants as suitable biomarkers of diabetic complications risk factors. Methods A total of 90 patients (70 patients with or without diabetic complications +20 normal healthy) were examined by evaluating the level of lipid peroxidation, nitrogen monoxide (NO), fasting blood glucose, glycated haemoglobin (HbA1c), enzymatic and non-enzymatic antioxidants using standard spectrophotometric methods. Results The fasting blood glucose and HbA1c levels were respectively 2.05 and 2.32 times higher in the group of patients with diabetes and complications (DPWC) compared to those of healthy persons. A statistically higher level of malondialdehyde (MDA), NO and TAC was observed in a group of patients with diabetes and complications compared to those without complications (DPNC). A significant positive correlation was found between catalase (CAT) and fasting blood glucose while a significant and negative correlation was noted between reduced glutathione (GSH) and fasting blood glucose. Also was noted a significant relationship between HbA1c and other markers of oxidative stress. Conclusions The results suggest that the plasma levels of CAT, TAC and reduced glutathione could give information on the risk of developing complications of diabetes, considering that the modification of these biomarkers levels were associated with oxidative stress. |
| Databáze: | OpenAIRE |
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