Clinical pharmacokinetic studies of a human haemopoietic growth factor, GM-CSF
| Autor: | N. I. Nissen, Doris Hovgaard, B. T. Mortensen, S. Schifter |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
medicine.medical_specialty Injections Subcutaneous medicine.medical_treatment Clinical Biochemistry Clinical pharmacokinetic Biochemistry Leukocyte Count Bolus (medicine) Pharmacokinetics Internal medicine medicine Humans business.industry Lymphoma Non-Hodgkin Growth factor Granulocyte-Macrophage Colony-Stimulating Factor Half-life Radioimmunoassay General Medicine Middle Aged Peripheral Haematopoiesis Endocrinology Injections Intravenous business Half-Life |
| Zdroj: | European Journal of Clinical Investigation. 22:45-49 |
| ISSN: | 1365-2362 0014-2972 |
| DOI: | 10.1111/j.1365-2362.1992.tb01934.x |
| Popis: | The pharmacokinetics of glycosylated recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) was studied following intravenous (i.v.) and subcutaneous (s.c.) bolus injection of rhGM-CSF, 8 micrograms kg-1 employing a sensitive radioimmunoassay. After a single i.v. bolus injection, an initial high serum level of rhGM-CSF was observed, followed by a rapid decrease that occurred in two phases with a half-life (t1/2) alpha of 20.0 +/- 5 min and a t1/2 beta of 68.3 +/- 8 min. Following s.c. bolus injection the absorption was more prolonged. Peak serum concentrations did not occur until about 15-20 h, and were followed by a more protracted elimination than by the i.v. route. In all patients the single rhGM-CSF injection led to an increase in peripheral white blood cells (WBC), after a temporary drop of 2-5 h duration. The increase in WBC was of longer duration after s.c. than after i.v. bolus treatment. Since the subcutaneous administration leads to prolonged serum concentration of rhGM-CSF and prolonged increase in peripheral WBC, it seems preferable to i.v. bolus injection, and as effective as continuous i.v. infusion. |
| Databáze: | OpenAIRE |
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