On the relative importance of D-1 vs. D-2 dopaminergic receptors in the control of audiogenic seizures in ethanol withdrawn rats
| Autor: | Olgierd Pucilowski, Ewa Trzaskowska, Pawel Krza̧ścik, Wojciech Kostowski, Adelajda Staniszewska |
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| Rok vydání: | 1989 |
| Předmět: |
Male
Agonist medicine.medical_specialty medicine.drug_class Toxicology Receptors Dopamine chemistry.chemical_compound Seizures Internal medicine Convulsion medicine Animals Pharmacology (medical) Bromocriptine Pharmacology SCH-23390 Ethanol Chemistry Dopaminergic Antagonist Rats Inbred Strains Benzazepines Rats Substance Withdrawal Syndrome Psychiatry and Mental health Endocrinology Acoustic Stimulation Dopamine receptor Autoreceptor 2 3 4 5-Tetrahydro-7 8-dihydroxy-1-phenyl-1H-3-benzazepine medicine.symptom medicine.drug |
| Zdroj: | Drug and Alcohol Dependence. 24:265-267 |
| ISSN: | 0376-8716 |
| Popis: | Bromocriptine, a mixed D-1/D-2 dopaminergic receptor agonist and SKF 38393, a D-1 specific agonist were found to alleviate the incidence and intensity of audiogenic convulsions in ethanol withdrawn rats. (+) and (-)3-PPP, putative D-2 autoreceptor agonists, were without effect in the test. SCH 23390, a D-1 specific antagonist did not influence seizure intensity in ethanol withdrawn or ethanol naive animals. It is suggested that D-1 receptors may play a role in convulsive response during ethanol withdrawal. |
| Databáze: | OpenAIRE |
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