Salmeterol or doxycycline do not inhibit acute bronchospasm and airway inflammation in cats with experimentally-induced asthma
| Autor: | Pascal Gustin, Nathalie Kirschvink, Jérôme Leemans, Cécile Clercx, Frédéric Billen, Frédéric Snaps, Frederique Bernaerts |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Time Factors Prednisolone Anti-Inflammatory Agents Administration Oral Cholinergic Agonists Cat Diseases Bronchospasm Administration Inhalation Medicine Animals Albuterol Prospective Studies Adrenergic beta-2 Receptor Agonists Salmeterol Xinafoate Ascaris suum Asthma Doxycycline CATS Cross-Over Studies General Veterinary Inhalation medicine.diagnostic_test Bronchial Spasm business.industry respiratory system medicine.disease respiratory tract diseases Bronchodilator Agents Bronchoalveolar lavage Anesthesia Antigens Helminth Cats Animal Science and Zoology Carbachol Female Salmeterol medicine.symptom business medicine.drug |
| Zdroj: | Veterinary journal (London, England : 1997). 192(1) |
| ISSN: | 1532-2971 |
| Popis: | The objective of this study was to determine if inhaled salmeterol, a long-acting β(2)-adrenergic agonist, and oral doxycycline, a tetracycline antibiotic displaying matrix metalloproteinase (MMP) inhibitory activity, reduce airway inflammation and obstruction in cats with experimentally-induced asthma. Eight Ascaris suum (AS)-sensitised cats were enrolled in a prospective study in which they underwent four AS-challenges at 1 month intervals. The challenged animals were given no treatment or were treated on 4 consecutive days with either: (1) oral prednisolone (1mg/kg twice daily), (2) inhaled salmeterol (50 μg twice daily), or (3) oral doxycycline (5mg/kg twice daily), according to a randomised cross-over design. Inhibition of allergen-induced early (EAR) and late (LAR) asthmatic reactions were assessed by barometric whole-body plethysmography. Cytology and measurement of MMP-2 and -9 activities were carried out on bronchoalveolar lavage fluid (BALF). Although none of the treatments prevented the EAR, prednisolone treatment inhibited the LAR. Relative to untreated cats, the eosinophil percentage and MMP-2 activity in BALF were significantly reduced following prednisolone treatment (P |
| Databáze: | OpenAIRE |
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