Association between ANGPTL-4 and the proinflammatory process in cancer cachexia patients
| Autor: | Claudia Maria Oller do Nascimento, Marilia Seelaender, Nelson Inácio Pinto Neto, Valter Tadeu Boldarine, Lila Missae Oyama, Ana Claudia Losinskas Hachul, Paulo Sérgio Martins de Alcântara, José Pinhata Otoch, Flavio Tokeshi, Estefania Simoes Fernandez, Joanna Darck Carola Correia Lima |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty tumor Colorectal cancer ANGPTL-4 proinflammatory process Gastroenterology cachexia CAQUEXIA Cachexia Proinflammatory cytokine 03 medical and health sciences 0302 clinical medicine Internal medicine parasitic diseases Medicine business.industry Cancer cachexia Cancer medicine.disease cytokines 030104 developmental biology Oncology 030220 oncology & carcinogenesis Cancer metabolism Subcutaneous adipose tissue business Biomedical sciences Research Paper |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP Oncotarget |
| Popis: | // Nelson Inacio Pinto Neto 1 , Valter Tadeu Boldarine 1 , Ana Claudia Losinskas Hachul 1 , Lila Missae Oyama 1 , Joanna Darck Carola Correia Lima 3 , Estefania Simoes Fernandez 3 , Jose Pinhata Otoch 2 , Paulo Sergio Martins de Alcântara 2 , Flavio Tokeshi 2 , Marilia Cerqueira Leite Seelaender 2 , 3 and Claudia Maria da Penha Oller do Nascimento 1 1 Departamento de Fisiologia, Universidade Federal de Sao Paulo, Escola Paulista de Medicina, Sao Paulo, Brazil 2 Department of Clinical Surgery, University of Sao Paulo, Sao Paulo, Brazil 3 Institute of Biomedical Sciences, Cancer Metabolism Research Group, University of Sao Paulo, Sao Paulo, Brazil Correspondence to: Nelson Inacio Pinto Neto, email: nelson_nip@hotmail.com Keywords: ANGPTL-4; cytokines; tumor; cachexia; proinflammatory process Received: May 20, 2019 Accepted: September 24, 2019 Published: PUBLISHED_DATE ABSTRACT Background Contradictory results are reported for the role of angiopoietin-like 4 (ANGPTL-4) in the development of cancer-cachexia and inflammation, given its importance in angiogenesis and inflammatory signaling. Our aim was to analyze the levels of ANGPTL-4 in colorectal cancer patients with a stable weight and those with cachexia in order to establish a relationship between ANGPTL-4 and the inflammatory process. Results Plasma and tumor levels of ANGPTL-4 were higher in CC in comparison to other groups. A positive association was verified between plasmatic ANGPTL-4 and NFκB levels in tumor from CC. In WSC, we identified an association between the plasmatic ANGPTL-4, IL-15, and IL-10 in tumor and IL-15 in MES. Increased levels of NFκB and TNF-R1 in MES were detected in CC in comparison to WSC. Specifically in CC-group, a positive correlation was found between ANGPTL-4 levels and those of IL-1β, TNF-α, and NFκB in tumor, along with an association between ANGPTL-4 levels with IL-1β and MCP-1 levels in tumor; and ANGPTL-4 and IL-1β levels in MES. Methods We studied 102 patients, who were divided into three groups: control patients (C, n=37), cancer patients with a stable weight (WSC, n=23), and cancer-cachexia patients (CC, n=42). Samples of plasma, tumor, mesenteric (MES) and subcutaneous adipose tissue were removed for the determination of ANGPTL-4 levels and other proinflammatory factors. Conclusions ANGPTL-4 levels were higher in plasma and tumor of CC-group, and positively associated with pro-inflammatory and pro-tumorigenic factors. Our results suggest an opposite effect of ANGPTL-4 depending on the concentration and presence of cachexia. |
| Databáze: | OpenAIRE |
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