Thoracic spinal cord neuromodulation obtunds dorsal root ganglion afferent neuronal transduction of the ischemic ventricle
| Autor: | Sarah M. Ardell, J. Andrew Armour, Jeffrey L. Ardell, Mathew Hammer, David D. Gibbons, Siamak Salavatian |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Nervous system Sensory Receptor Cells Physiology Heart Ventricles Myocardial Infarction Action Potentials Stimulation Dogs Dorsal root ganglion Ganglia Spinal Physiology (medical) Reflex medicine Animals Spinal Cord Stimulation business.industry Spinal cord Spinal column Neuromodulation (medicine) Disease Models Animal medicine.anatomical_structure nervous system Ventricle Ventricular Fibrillation Female Cardiology and Cardiovascular Medicine business Transduction (physiology) Neuroscience Research Article |
| Zdroj: | Am J Physiol Heart Circ Physiol |
| ISSN: | 1522-1539 0363-6135 |
| DOI: | 10.1152/ajpheart.00257.2019 |
| Popis: | Aberrant afferent signaling drives adverse remodeling of the cardiac nervous system in ischemic heart disease. The study objective was to determine whether thoracic spinal dorsal column stimulation (SCS) modulates cardiac afferent sensory transduction of the ischemic ventricle. In anesthetized canines ( n = 16), extracellular activity generated by 62 dorsal root ganglia (DRG) soma (T1-T3), with verified myocardial ischemic (MI) sensitivity, were evaluated with and without 20-min preemptive SCS (T1-T3 spinal level; 50 Hz, 90% motor threshold). Transient MI was induced by 1-min coronary artery occlusion (CAO) of the left anterior descending (LAD) or circumflex (LCX) artery, randomized as to sequence. LAD and LCX CAO activated cardiac-related DRG neurons (LAD: 0.15 ± 0.04–1.05 ± 0.20 Hz, P < 0.00002; LCX: 0.08 ± 0.02–1.90 ± 0.45 Hz, P < 0.0003). SCS decreased basal neuronal activity of neurons that responded to LAD (0.15 ± 0.04 to 0.02 ± 0.01 Hz, P < 0.006) and LCX (0.08 ± 0.02 to 0.02 ± 0.01 Hz, P < 0.003). SCS suppressed responsiveness to transient MI (LAD: 1.05 ± 0.20–0.03 ± 0.01 Hz; P < 0.0001; LCX: 1.90 ± 0.45–0.03 ± 0.01 Hz; P < 0.001). Suprathreshold SCS (1 Hz) did not activate DRG neurons antidromically ( n = 10 animals). Ventricular fibrillation (VF) was associated with a rapid increase in DRG activity to a maximum of 4.39 ± 1.07 Hz at 20 s after VF induction and a return to 90% of baseline within 10 s thereafter. SCS obtunds the capacity of DRG ventricular neurites to transduce the ischemic myocardium to second-order spinal neurons, a mechanism that would blunt reflex sympathoexcitation to myocardial ischemic stress, thereby contributing to its capacity to cardioprotect. NEW & NOTEWORTHY Aberrant afferent signaling drives adverse remodeling of the cardiac nervous system in ischemic heart disease. This study determined that thoracic spinal column stimulation (SCS) obtunds the capacity of dorsal root ganglia ventricular afferent neurons to transduce the ischemic myocardium to second-order spinal neurons, a mechanism that would blunt reflex sympathoexcitation to myocardial ischemic stress. This modulation does not reflect antidromic actions of SCS but likely reflects efferent-mediated changes at the myocyte-sensory neurite interface. Listen to this article’s corresponding podcast at https://ajpheart.podbean.com/e/spinal-cord-stimulation-blunts-dorsal-root-transduction-of-the-ischemic-ventricle/ . |
| Databáze: | OpenAIRE |
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