TAN-1323 C and D, New Concanamycin-group Antibiotics; Detection of the Angiostatic Activity with a Wide Range of Macrolide Antibiotics
| Autor: | Yukimasa Nozaki, Shigemi Iinuma, Tsuneaki Hida, Masayuki Muroi, Takafumi Ishii |
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| Rok vydání: | 1995 |
| Předmět: |
Magnetic Resonance Spectroscopy
Chemical Phenomena medicine.drug_class Antibiotics Chick Embryo Biology Tylosin Streptomyces Macrolide Antibiotics Microbiology Mice chemistry.chemical_compound Allantois Drug Discovery medicine Animals Humans Pharmacology Mice Inbred BALB C Neovascularization Pathologic Chemistry Physical Streptomycetaceae Bafilomycin Streptomyces purpurascens Biological activity 3T3 Cells Chorion biology.organism_classification Anti-Bacterial Agents chemistry Fermentation Endothelium Vascular Macrolides Cell Division |
| Zdroj: | The Journal of Antibiotics. 48:12-20 |
| ISSN: | 1881-1469 0021-8820 |
| Popis: | We detected potent angiostatic activity in a MeOH extract from the mycelia of microbial strain S-45628 in the chick chorioallantoic membrane (CAM) assay. The producer was taxonomically characterized as Streptomyces purpurascens. Active principles designated TAN-1323 A-D were isolated and determined to be 18-membered macrolide antibiotics; components C and D are new members of this group, while components A and B are identical to concanamycins C and A, respectively. When tested in the CAM assay, components B and D gave huge avascular zones at the extremely low doses of 10-100 ng/disk, although components A and C showed far weaker activity due to their preferential tissue-damaging effect on the CAM. The discovery that these 18-membered macrolide antibiotics are angiostatic substances prompted us to examine other types of macrolide antibiotics, leading to the discovery that 16-membered macrolide antibiotics such as bafilomycin C1, tylosin and leucomycin also show angiostatic activity on the CAM. Thus, angiostatic potential is widely distributed among macrolide antibiotics. The mechanism of action of these macrolide antibiotics is also discussed. |
| Databáze: | OpenAIRE |
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