Interactions of ginsenosides with ligand-bindings of GABAA and GABAB receptors
| Autor: | Hack-Seang Kim, T. Kimura, I. K. Ho, Ki Wan Oh, P.A. Saunders, H.M. Rheu |
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| Rok vydání: | 1994 |
| Předmět: |
Male
Baclofen Ginsenosides Stereochemistry Molecular Sequence Data Herb-Drug Interactions Saponin Panax Flunitrazepam GABAB receptor Ligands Sulfur Radioisotopes Tritium Rats Sprague-Dawley Bridged Bicyclo Compounds chemistry.chemical_compound Animals Pharmacology chemistry.chemical_classification Plants Medicinal Muscimol GABAA receptor Saponins Bridged Bicyclo Compounds Heterocyclic Receptors GABA-A Ligand (biochemistry) In vitro Rats Carbohydrate Sequence Receptors GABA-B chemistry Ginsenoside |
| Zdroj: | General Pharmacology: The Vascular System. 25:193-199 |
| ISSN: | 0306-3623 |
| Popis: | 1. 1. Total saponin fraction decreased the affinity of specific [ 3 H]muscimol binding without changes in B max . Ginsenoside Rb 1 Rb 2 , Rc, Re, Rf and Rg 1 inhibited the specific [ 3 H]muscimol binding to the high-affinity site. 2. 2. Total saponin fraction increased the affinity of specific [ 3 H]flunitrazepam binding. Ginsenoside Re and Rf enhanced specific [ 3 H]flunitrazepam binding. 3. 3. Total saponin fraction decreased the affinity of specific [ 35 S]TBPS binding without changes in B max . Ginsenosides did not affect specific or non-specific [ 35 S]TBPS binding. 4. 4. Total saponin fraction decreased the affinity of specific [ 3 H]baclofen binding without changes in B max . Ginsenoside Rc inhibited specific [ 3 H]baclofen binding. |
| Databáze: | OpenAIRE |
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