Studies on the interaction between ethanol and amfonelic acid
| Autor: | K. Von Hungen, C.K. Kodama, J.T. Cummins, M.K. Menon |
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| Rok vydání: | 1987 |
| Předmět: |
Agonist
Male medicine.drug_class medicine.medical_treatment Stimulation Pharmacology Body Temperature Cellular and Molecular Neuroscience chemistry.chemical_compound Mice Nalidixic Acid Species Specificity Dopamine medicine Animals Drug Interactions Naphthyridines Amphetamine Mice Inbred BALB C Ethanol Dopaminergic Stimulant Mice Inbred C57BL Biochemistry chemistry Amfonelic acid Sleep medicine.drug |
| Zdroj: | Neuropharmacology. 26(2-3) |
| ISSN: | 0028-3908 |
| Popis: | Amfonelic acid (AFA), a non-amphetamine central stimulant dose-dependently reduced the hypnotic effect of ethanol in C57B1/6 mice. It did not enhance the elimination of ethanol. Amfonelic acid failed to modify the duration of pentobarbitone-induced hypnosis or the ethanol-induced hypothermia in these animals. Combined treatment with amfonelic acid and a lipophilic α1-adrenoceptor agonist was not more effective than amfonelic acid alone in blocking ethanol hypnosis. The stimulation of locomotor activity by amfonelic acid in C57B1/6 mice was more sensitive to the blocking effect of ethanol than stimulation induced by d-amphetamine. The blocking effect of amfonelic acid, but not that of d-amphetamine, on the effects of ethanol developed tolerance. In pimozide-pretreated mice, amfonelic acid failed to reduce the ethanol-induced hypnosis. Hence it appears that dopamine (DA) released by amfonelic acid is responsible for its antagonism of ethanol. However, though amfonelic acid acted as a strong releaser of DA in Swiss-Webster, CD-1, DBA-2 and BALB/c mice, in these strains it failed to reduce the effect of ethanol. Moreover, methylphenidate, a dopaminergic stimulant, which acts by a mechanism similar to that of amfonelic acid was not effective in reducing the hypnotic effect of ethanol in C57B1/6 mice. For these reasons, additional mechanisms may have to be considered to explain this strain-dependent effect of amfonelic acid. |
| Databáze: | OpenAIRE |
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