Antituberculosis drugs and hepatotoxicity among hospitalized patients in Jos, Nigeria
| Autor: | Gomerep Samuel Simji, Isaac O Abah, Hafsat Olufunke Jimoh, Joseph Anejo-Okopi, Rachael U. Odesanya, Augustine O. Ebonyi, Samson E. Isa, Patrick Idoko, Nathan Y. Shehu |
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| Rok vydání: | 2015 |
| Předmět: |
Microbiology (medical)
Adult Male medicine.medical_specialty Tuberculosis Antituberculosis Bilirubin lcsh:QR1-502 Antitubercular Agents Nigeria HIV Infections Pharmacology lcsh:Microbiology Cohort Studies 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Interquartile range Internal medicine medicine Humans 030212 general & internal medicine Aspartate Aminotransferases Adverse effect Retrospective Studies Toxicity biology business.industry Tuberculin Test Incidence (epidemiology) Incidence Retrospective cohort study Alanine Transaminase Middle Aged medicine.disease Hospitalization Infectious Diseases chemistry Alanine transaminase Liver biology.protein 030211 gastroenterology & hepatology Female Chemical and Drug Induced Liver Injury business Body mass index |
| Zdroj: | International Journal of Mycobacteriology, Vol 5, Iss 1, Pp 21-26 (2016) |
| ISSN: | 2212-554X |
| Popis: | Background Tuberculosis (TB) could be fatal if left untreated, however, adverse effects of anti-TB medications (anti-TBs) themselves may limit treatment. We determined the incidence and clinical characteristics of hepatotoxicity in hospitalized patients receiving first-line anti-TB treatment. Methods A retrospective cohort study of patients aged ⩾18 years seen at the medical wards of the Jos University Teaching Hospital from January 2013 to June 2013 was carried out. Data were retrieved for 110 patients who were prescribed anti-TBs. Their demographic and clinical characteristics were described, and the incidence of symptomatic hepatotoxicity determined. The incidence of hepatotoxicity by strict American Thoracic Society criteria (symptomatic hepatotoxicity plus alanine transaminase in IU/L levels >3 × upper limit of normal) was also determined. Results Twenty patients developed symptomatic hepatotoxicity, giving an incidence of 18.2%. Furthermore, 18 (16.4%) patients had hepatotoxicity according to the American Thoracic Society criteria. Those with symptomatic hepatotoxicity unexpectedly had lower baseline alanine transaminase interquartile range (IQR) (35 [16–63] vs. 67 [4–226]; p = .04) and bilirubin (μmol/L): total IQR (15.3 [10.2–74.8] vs. 20.4 [20.4–20.4]; p = .01) and conjugated IQR (7.6 [5.1–34.8] vs. 10.2 [10.2–10.2]; p = .004). However, there were no significant differences in age, sex, body mass index, and duration of anti-TB treatment, human immunodeficiency virus infection status, antiretroviral therapy status, alcohol consumption, and the presence of hepatitis B surface antigen or hepatitis C virus antibody. Conclusion Hepatotoxicity due to first-line anti-TBs, whether based on clinical features alone or backed by liver chemistry, is common among hospitalized patients in our environment. Studies to determine the predictors of hepatotoxicity to guide clinical interventions aimed at the prevention or timely identification of cases are needed. |
| Databáze: | OpenAIRE |
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