Janus cyclic peptide-polymer nanotubes
| Autor: | Sébastien Perrier, Philip G. Young, Katrina A. Jolliffe, Maarten Danial, Carmen M.-N. Tran |
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| Rok vydání: | 2013 |
| Předmět: |
chemistry.chemical_classification
Quantitative Biology::Biomolecules Multidisciplinary Materials science General Physics and Astronomy Nanotechnology General Chemistry Polymer Condensed Matter::Mesoscopic Systems and Quantum Hall Effect General Biochemistry Genetics and Molecular Biology Cyclic peptide Quantitative Biology::Subcellular Processes Condensed Matter::Soft Condensed Matter Condensed Matter::Materials Science Corona (optical phenomenon) chemistry Janus Mixing (physics) Conjugate |
| Zdroj: | Nature communications. 4 |
| ISSN: | 2041-1723 |
| Popis: | Self-assembled nanotubular structures have numerous potential applications but these are limited by a lack of control over size and functionality. Controlling these features at the molecular level may allow realization of the potential of such structures. Here we report a new generation of self-assembled cyclic peptide-polymer nanotubes with dual functionality in the form of either a Janus or mixed polymeric corona. A 'relay' synthetic strategy is used to prepare nanotubes with a demixing or mixing polymeric corona. Nanotube structure is assessed in solution using (1)H-(1)H nuclear Overhauser effect spectroscopy NMR, and in bulk using differential scanning calorimetry. The Janus nanotubes form artificial pores in model phospholipid bilayers. These molecules provide a viable pathway for the development of intriguing nanotubular structures with dual functionality via a demixing or a mixing polymeric corona and may provide new avenues for the creation of synthetic transmembrane protein channel mimics. |
| Databáze: | OpenAIRE |
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