Topical Use of Sucralfate in Epithelial Wound Healing: Clinical Evidence and Molecular Mechanisms of Action
| Autor: | Roberto Bei, Andrea Modesti, Giovanni Tumino, Laura Masuelli, Mario Turriziani |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Pathology
medicine.medical_specialty Neovascularization Physiologic Dermatitis Pharmacology Patents as Topic Matrix Metalloproteinases Wound Healing Ulcer Sucralfate Granulation Tissue Epithelium Fibroblast Growth Factors Animals Humans epithelial wound growth factors Drug Discovery Mucositis Immunology and Allergy Medicine topical Physiologic Neovascularization Settore MED/04 - Patologia Generale Topical drug integumentary system inflammation sucralfate healing business.industry Granulation tissue General Medicine medicine.disease Duodenal ulcer medicine.anatomical_structure Hemostasis business Wound healing medicine.drug |
| Zdroj: | Recent Patents on Inflammation & Allergy Drug Discovery. 4:25-36 |
| ISSN: | 1872-213X |
| DOI: | 10.2174/187221310789895649 |
| Popis: | Sucralfate is a basic aluminium salt of sucrose octasulphate which was orally employed for prevention and treatment of several gastrointestinal diseases including gastroesophageal reflux, gastric and duodenal ulcer. Recent studies have employed sucralfate as a topical drug for the healing of several types of epithelial wounds such as ulcers, inflammatory dermatitis, mucositis and burn wounds. Epithelial wound healing is a well orchestrated process involving hemostasis, inflammatory reaction, cell proliferation and tissue remodelling which leads to granulation tissue development and filling of the wound space. This report will review clinical evidences on the use of topical sucralfate for the management of epithelial lesions and deal with the current knowledge on the molecular mechanisms of action of this compound towards the epithelial wound healing process and will also discuss relevant patents. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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