The Gut Microbiota of Wild Mice

Autor: Eleanor M. Riley, Mark Viney, Stephen Abolins, Christian Bourne, Laura Weldon, Luca Lenzi
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Leptin
Male
Nematoda
lcsh:Medicine
Gut flora
DNA
Bacterial/isolation & purification

Cecum
Mice
fluids and secretions
Bacteroidetes/isolation & purification
lcsh:Science
Phylogeny
0303 health sciences
Mites
Multidisciplinary
biology
Geography
Intestines
medicine.anatomical_structure
England
Cecum/microbiology
Viruses
Female
Research Article
DNA
Bacterial

Firmicutes
Firmicutes/isolation & purification
Intestine
Large/microbiology

digestive system
Microbiology
Caecum
03 medical and health sciences
medicine
Animals
Microbiome
Intestine
Large

030304 developmental biology
030306 microbiology
Host (biology)
Bacteroidetes
lcsh:R
Body Weight
Computational Biology
biology.organism_classification
Intestines/microbiology
Gastrointestinal Microbiome
stomatognathic diseases
Nematode
Leptin/blood
Mice/microbiology
Microbial genetics
lcsh:Q
Zdroj: Weldon, L, Abolins, S, Lenzi, L, Bourne, C, Riley, E M & Viney, M 2015, ' The Gut Microbiota of Wild Mice ', PLoS ONE, vol. 10, no. 8, pp. e0134643 . https://doi.org/10.1371/journal.pone.0134643
Weldon, L, Abolins, S, Lenzi, L, Bourne, C, Riley, E M & Viney, M 2015, ' The Gut Microbiota of Wild Mice ', PLoS ONE, vol. 10, no. 8, e0134643 . https://doi.org/10.1371/journal.pone.0134643
PLoS ONE, Vol 10, Iss 8, p e0134643 (2015)
PLoS ONE
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0134643
Popis: The gut microbiota profoundly affects the biology of its host. The composition of the microbiota is dynamic and is affected by both host genetic and many environmental effects. The gut microbiota of laboratory mice has been studied extensively, which has uncovered many of the effects that the microbiota can have. This work has also shown that the environments of different research institutions can affect the mouse microbiota. There has been relatively limited study of the microbiota of wild mice, but this has shown that it typically differs from that of laboratory mice (and that maintaining wild caught mice in the laboratory can quite quickly alter the microbiota). There is also inter-individual variation in the microbiota of wild mice, with this principally explained by geographical location. In this study we have characterised the gut (both the caecum and rectum) microbiota of wild caught Mus musculus domesticus at three UK sites and have investigated how the microbiota varies depending on host location and host characteristics. We find that the microbiota of these mice are generally consistent with those described from other wild mice. The rectal and caecal microbiotas of individual mice are generally more similar to each other, than they are to the microbiota of other individuals. We found significant differences in the diversity of the microbiotas among mice from different sample sites. There were significant correlations of microbiota diversity and body weight, a measure of age, body-mass index, serum concentration of leptin, and virus, nematode and mite infection.
Databáze: OpenAIRE
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