PlexinD1 and Sema3E determine laminar positioning of heterotopically projecting callosal neurons
| Autor: | Pascal Salin, Mike Altounian, Carlos G. Briz, Anaïs Bellon, Micaela Roque, Marta Nieto, Fanny Mann, Mélanie Hocine, Theodora Velona, Sophie Chauvet |
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| Přispěvatelé: | Institut de Biologie du Développement de Marseille (IBDM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (France), Aix-Marseille Université, Agence Nationale de la Recherche (France), Fondation pour la Recherche Médicale, Institut Universitaire de France |
| Jazyk: | angličtina |
| Rok vydání: | 1970 |
| Předmět: |
0301 basic medicine
Male MESH: Neuroanatomical Tract-Tracing Techniques [SDV]Life Sciences [q-bio] [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology MESH: Membrane Glycoproteins MESH: Neurons MESH: Semaphorins Striatum Semaphorins Somatosensory system Corpus callosum Corpus Callosum Mice 0302 clinical medicine MESH: Animals Neurons Neocortex Membrane Glycoproteins Intracellular Signaling Peptides and Proteins Motor Cortex Commissure 3. Good health Neuroanatomical Tract-Tracing Techniques medicine.anatomical_structure Female Biology MESH: Corpus Callosum MESH: Motor Cortex MESH: Somatosensory Cortex 03 medical and health sciences Cellular and Molecular Neuroscience MESH: Mice Inbred C57BL MESH: Intracellular Signaling Peptides and Proteins medicine Animals Molecular Biology MESH: Mice Cell Biology Somatosensory Cortex Retrograde tracing MESH: Male Mice Inbred C57BL 030104 developmental biology Diverse population nervous system Axon guidance Neuroscience MESH: Female 030217 neurology & neurosurgery |
| Zdroj: | Molecular and Cellular Neuroscience Molecular and Cellular Neuroscience, 1970, 100, pp.103397. ⟨10.1016/j.mcn.2019.103397⟩ Molecular and Cellular Neuroscience, Elsevier, 2019, 100, pp.103397. ⟨10.1016/j.mcn.2019.103397⟩ Digital.CSIC. Repositorio Institucional del CSIC instname Molecular and Cellular Neuroscience, Elsevier, 1970, 100, pp.103397. ⟨10.1016/j.mcn.2019.103397⟩ Digital.CSIC: Repositorio Institucional del CSIC Consejo Superior de Investigaciones Científicas (CSIC) Molecular and Cellular Neuroscience, 2019, 100, pp.103397. ⟨10.1016/j.mcn.2019.103397⟩ |
| ISSN: | 1044-7431 1095-9327 |
| DOI: | 10.1016/j.mcn.2019.103397⟩ |
| Popis: | © 2019 The Authors. The corpus callosum is the largest bundle of commissural fibres that transfer information between the two cerebral hemispheres. Callosal projection neurons (CPNs) are a diverse population of pyramidal neurons within the neocortex that mainly interconnect homotopic regions of the opposite cortices. Nevertheless, some CPNs are involved in heterotopic projections between distinct cortical areas or to subcortical regions such as the striatum. In this study, we showed that the axon guidance receptor PlexinD1 is expressed by a large proportion of heterotopically projecting CPNs in layer 5A of the primary somatosensory (S1) and motor (M1) areas. Retrograde tracing of M1 CPNs projecting to the contralateral striatum revealed the presence of ectopic neurons aberrantly located in layers 2/3 of Plxnd1 and Sema3e mutant cortices. These results showed that Sema3E/PlexinD1 signalling controls the laminar distribution of heterotopically projecting CPNs. This work was supported by the Centre National de la Recherche Scientifique (CNRS), France; Aix Marseille Université, France; Agence Nationale de la Recherche, ANR-12-BSV4-0012-01, France to F.M.; Fondation pour la Recherche Medicale, Equipe FRM DEQ20150331728, France to F.M., Institut Universitaire de France, France, to S.C.. T.V. is a recipient of doctoral fellowships from the Integrative and Clinical Neuroscience PhD Program and from the Fondation pour la Recherche Medicale, France. |
| Databáze: | OpenAIRE |
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