Re-186(Sn) HEDP for treatment of multiple metastatic foci in bone: human biodistribution and dosimetric studies
| Autor: | S J Lukes, Stephen R. Thomas, K. F. Libson, Harry R. Maxon, Craig C. Williams, Edward Deutsch, S Ali |
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| Rok vydání: | 1988 |
| Předmět: |
Adult
Male Radioisotopes Biodistribution Pathology medicine.medical_specialty business.industry medicine.medical_treatment Bone Neoplasms Etidronic Acid Radiotherapy Dosage Limiting Middle Aged Therapeutic radiation Metastatic carcinoma Radiation therapy Rhenium medicine Red Marrow Humans Radiology Nuclear Medicine and imaging Female Tissue Distribution business Aged |
| Zdroj: | Radiology. 166(2) |
| ISSN: | 0033-8419 |
| Popis: | Investigation of the biodistribution of subtherapeutic amounts of a new, chromatographically purified rhenium-186(tin) hydroxyethylidene diphosphonate radiopharmaceutical have been completed in five patients with metastatic carcinoma to bone. The new agent localizes in metastatic foci in bone in the same manner as do standard technetium-99m diphosphonate bone-scanning agents and appears able to deliver therapeutic radiation doses of thousands of rads (tens of grays) to these metastatic foci while limiting the total red marrow dose to less than 75 rad (0.75 Gy). The simultaneous treatment of multiple metastatic foci in bone appears feasible with this new agent. |
| Databáze: | OpenAIRE |
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