Predictors for Bacteremia in Febrile Sickle Cell Disease Children in the Post-7-Valent Pneumococcal Conjugate Vaccine Era
| Autor: | Todd P. Chang, Worapant Kriengsoontorkij, Vincent J. Wang, Linda S. Chan |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Heptavalent Pneumococcal Conjugate Vaccine Adolescent Population Bacteremia Anemia Sickle Cell medicine.disease_cause Pneumococcal conjugate vaccine Pneumococcal Vaccines Young Adult Risk Factors Streptococcus pneumoniae medicine Humans Risk factor Child education History Ancient Retrospective Studies education.field_of_study business.industry Incidence Incidence (epidemiology) Infant Newborn Hematology bacterial infections and mycoses medicine.disease Oncology Pneumococcal vaccine Child Preschool Pediatrics Perinatology and Child Health Female business medicine.drug |
| Zdroj: | Journal of Pediatric Hematology/Oncology. 35:377-382 |
| ISSN: | 1077-4114 |
| Popis: | OBJECTIVES The objective of this study was to determine the incidence of bacteremia in febrile sickle cell disease (SCD) children before and after the 7-valent pneumococcal vaccine (PCV7), and to determine clinical factors associated with bacteremia following PCV7. PATIENTS AND METHODS We reviewed all febrile events in SCD children from 1993 to 2009 at a tertiary care pediatric center, comparing general bacteremia and pneumococcal bacteremia incidence for 3 time periods around the PCV7. Univariate analysis and stepwise logistic regression identified clinical factors most associated with bacteremia in this population. RESULTS Of 466 SCD children identified, there were 2504 febrile events. We found 84 cases of bacteremia; 8 were pneumococcal. The general bacteremia incidence decreased significantly from 5.60% to 2.44% (P |
| Databáze: | OpenAIRE |
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