Engineering nanoparticle therapeutics for impaired wound healing in diabetes
| Autor: | Ali Coyle, Arghya Paul, Subrata Chakrabarti, Yasmeen Shamiya, Shruthi Polla Ravi |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
medicine.medical_treatment
02 engineering and technology Bioinformatics Regenerative medicine 03 medical and health sciences Diabetes mellitus Drug Discovery Diabetes Mellitus medicine Humans In patient 030304 developmental biology Pharmacology Wound Healing 0303 health sciences business.industry 021001 nanoscience & nanotechnology medicine.disease 3. Good health Impaired wound healing Cytokine Chronic disease Nanoparticles 0210 nano-technology Wound healing business Delayed healing |
| Zdroj: | Drug Discovery Today. 27:1156-1166 |
| ISSN: | 1359-6446 |
| DOI: | 10.1016/j.drudis.2021.11.024 |
| Popis: | Diabetes mellitus is a chronic disease characterized by increased blood glucose levels, leading to damage of the nerves blood vessels, subsequently manifesting as organ failures, wounds, or ulcerations. Wounds in patients with diabetes are further complicated because of reduced cytokine responses, infection, poor vascularization, and delayed healing process. Surface-functionalized and bioengineered nanoparticles (NPs) have recently gained attention as emerging treatment modalities for wound healing in diabetes. Here, we review emerging therapeutic NPs to treat diabetic wounds and highlight their discrete delivery mechanisms and sites of action. We further critically assess the current challenges of these nanoengineered materials for successful clinical translation and discuss their potential for growth in the clinical marketplace. |
| Databáze: | OpenAIRE |
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