Echocardiographic findings and plasma endothelin-1 levels in obese patients with and without obstructive sleep apnea
| Autor: | Fiorella Devito, Roberto Ria, Onofrio Resta, Vitaliano Nicola Quaranta, Pierluigi Carratù, Mauro Maniscalco, Valentina Anna Ventura, Marco Matteo Ciccone, Silvano Dragonieri, Angelo Vacca, Barbara Phillips, Simona Berardi |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Hypertension Pulmonary Polysomnography Statistics as Topic Comorbidity 030204 cardiovascular system & hematology Pulmonary function testing 03 medical and health sciences 0302 clinical medicine Reference Values Internal medicine medicine.artery medicine Humans Obesity Pulmonary Wedge Pressure Endothelial dysfunction Pulmonary wedge pressure Sleep Apnea Obstructive Endothelin-1 medicine.diagnostic_test business.industry Middle Aged medicine.disease Endothelin 1 Pulmonary hypertension Echocardiography Doppler Obstructive sleep apnea 030228 respiratory system Otorhinolaryngology Pulmonary artery Cardiology Female Neurology (clinical) business |
| Zdroj: | Sleep and Breathing. 20:613-619 |
| ISSN: | 1522-1709 1520-9512 |
| DOI: | 10.1007/s11325-015-1260-5 |
| Popis: | Obstructive sleep apnea (OSA) and obesity are increasingly prevalent worldwide. Both promote endothelial dysfunction contributing to systemic and pulmonary hypertension over time. Endothelin-1 (ET-1) plays a pivotal role in the development of pulmonary hypertension (PH). The aim of the present study was to assess the association between plasma ET-1 and echocardiographic findings in obese individuals with and without OSA, as well as in non-obese patients with OSA. Ninety-seven subjects (56 males) were enrolled in the study. All subjects underwent the following tests: venous endothelin-1 levels, pulmonary function testing, and arterial blood gas analysis. All patients except controls underwent transthoracic echocardiography and portable testing for sleep-disordered breathing. Plasma ET-1 levels were significantly higher in obese patients, both with and without OSA (respectively, n = 30 (mean value, 268.06 ± 49.56 pg/ml) and n = 32 (mean value, 263.12 ± 65.26 pg/ml)), compared with non-obese patients with OSA or to healthy controls (respectively, n = 20 (mean value, 149.8 ± 23.09 pg/ml) and n = 15 (mean value, 152.3 ± 27.64 pg/ml); p |
| Databáze: | OpenAIRE |
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