The diagnosis of hydatidiform mole by gonadotropic hormone assay using the South African frog, Xenopus laevis
| Autor: | Abner I. Weisman, Christopher W. Coates |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Pregnancy test
medicine.medical_specialty Endocrinology Diabetes and Metabolism media_common.quotation_subject Clinical Biochemistry Xenopus Hormone assay Biochemistry Xenopus laevis Endocrinology Pregnancy Internal medicine Mole medicine Animals Humans Ovulation media_common Aged biology Gonadotropic hormones Biochemistry (medical) Hydatidiform Mole medicine.disease biology.organism_classification Uterine Neoplasms Female Gonadotropins |
| Zdroj: | The Journal of clinical endocrinology and metabolism. 7(4) |
| ISSN: | 0021-972X |
| Popis: | SOON after Zondek and Aschheim made their brilliant discovery of the mouse test for pregnancy (1), Shapiro and Zwarenstein (5), Hogben (3), and Bellerby (2) showed the clinical application of the South African Frog (Xenopus laevis) to the finding of gonadotropic hormones in the urdne of pregnancy. In its natural habitat, the female of this unique species of amphibia never lays eggs unless stimulated by the male. Shapiro and Zwarenstein (6) segregated the females from the males and found that ovulation and external egg deposition could be induced entirely at will by simply injecting concentrates of pregnancy urine into these ever-ready and ever-willing female Xenopus. And thus, the early foundation for the frog test for pregnancy was laid. Since 1939, we in America have studied Xenopus laevis in detail and have performed thousands of pregnancy tests with the animal (7, 8, 9, 10, 11).1 In our earlier papers we have reported our excellent results, and have registered our keen delight with Xenopus as a test a... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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