Expression of EGF, EGFR, and proliferation in placentas from pregnancies complicated with preeclampsia
| Autor: | Jelena Marušić, Ivana Kuzmić Prusac, Marko Mimica, Sandra Zekic Tomas, Anna Berkovic, Indira Kosovic |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
medicine.medical_specialty Placenta Preeclampsia Andrology 03 medical and health sciences 0302 clinical medicine Pre-Eclampsia Pregnancy Internal medicine Internal Medicine medicine Humans Decidual cells reproductive and urinary physiology Cell Proliferation 030219 obstetrics & reproductive medicine Epidermal Growth Factor business.industry Obstetrics and Gynecology medicine.disease female genital diseases and pregnancy complications Villous trophoblast Egfr expression Trophoblasts ErbB Receptors Endocrinology 030220 oncology & carcinogenesis Extravillous trophoblast embryonic structures Female business |
| Zdroj: | Hypertension in pregnancy. 36(1) |
| ISSN: | 1525-6065 |
| Popis: | To investigate proliferation, EGF and EGFR expression of villous trophoblast (VTB), decidual cells (DC), and extravillous trophoblast (EVTB) in the placentas from pregnancies complicated with preeclampsia (PE) and to compare them with placentas from normal pregnancies.Twenty-nine PE placentas and 19 control placentas were studied for EGF and EGFR immunohistochemical expression (noted as week, moderate or strong). Proliferation was expressed as the proliferation index. The CK7 antibody was used to distinguish DC from EVTB.DC and EVTB proliferation was significantly higher in PE placentas. EGFR and EGF expression showed no significant difference.Higher DC and EVTB proliferation in PE could contribute to PE development. |
| Databáze: | OpenAIRE |
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