Intestinal Tumorigenesis Is Not Affected by Progesterone Signaling in Rodent Models

Autor: Patrick G. Groothuis, Daniel W. Hommes, Rutger J. Jacobs, Gijs R. van den Brink, Sietse Mosselman, Jarom Heijmans, James C. H. Hardwick, Izak Biemond, Vanesa Muncan, Laura Graven, Antwan G. Ederveen, Eveline S.M. de Jonge-Muller
Přispěvatelé: Luk, John, Tytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology Endocrinology Metabolism, Cancer Center Amsterdam, Gastroenterology and Hepatology, Amsterdam institute for Infection and Immunity, Faculteit der Geneeskunde
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Mouse
estrogen plus progestin colon-cancer medroxyprogesterone acetate colorectal-cancer postmenopausal women tumor progression receptor knockout mammary-gland mouse models mice
lcsh:Medicine
Small
Cell Transformation
chemistry.chemical_compound
Mice
Intestinal mucosa
Receptors
Gastrointestinal Cancers
Basic Cancer Research
Intestine
Small
Intestinal Mucosa
lcsh:Science
Progesterone
Cancer
Multidisciplinary
Intestinal Polyposis
Animal Models
Intestinal epithelium
Immunohistochemistry
Intestine
Colo-Rectal Cancer
medicine.anatomical_structure
Cell Transformation
Neoplastic
Oncology
Medicine
Signal transduction
Receptors
Progesterone
Aberrant crypt foci
Research Article
Signal Transduction
medicine.medical_specialty
General Science & Technology
medicine.drug_class
Colon
Mesenchyme
Gastroenterology and Hepatology
Biology
Model Organisms
Internal medicine
Progesterone receptor
Intestinal Neoplasms
medicine
Animals
Cell Proliferation
Neoplastic
Animal
Azoxymethane
Prevention
lcsh:R
Correction
Rats
Disease Models
Animal
Endocrinology
chemistry
Disease Models
lcsh:Q
Progestins
Digestive Diseases
Progestin
Zdroj: PLoS ONE
PloS one, vol 6, iss 7
PLoS ONE, 6(7). Public Library of Science
PLoS ONE, Vol 6, Iss 7, p e22620 (2011)
PLoS ONE, 6(7):e22620. Public Library of Science
PLoS ONE, 6(7)
ISSN: 1932-6203
Popis: Clinical data suggest that progestins have chemopreventive properties in the development of colorectal cancer. We set out to examine a potential protective effect of progestins and progesterone signaling on colon cancer development. In normal and neoplastic intestinal tissue, we found that the progesterone receptor (PR) is not expressed. Expression was confined to sporadic mesenchymal cells. To analyze the influence of systemic progesterone receptor signaling, we crossed mice that lacked the progesterone receptor (PRKO) to the Apc(Min/+) mouse, a model for spontaneous intestinal polyposis. PRKO-Apc(Min/+) mice exhibited no change in polyp number, size or localization compared to Apc(Min/+). To examine effects of progestins on the intestinal epithelium that are independent of the PR, we treated mice with MPA. We found no effects of either progesterone or MPA on gross intestinal morphology or epithelial proliferation. Also, in rats treated with MPA, injection with the carcinogen azoxymethane did not result in a difference in the number or size of aberrant crypt foci, a surrogate end-point for adenoma development. We conclude that expression of the progesterone receptor is limited to cells in the intestinal mesenchyme. We did not observe any effect of progesterone receptor signaling or of progestin treatment in rodent models of intestinal tumorigenesis.
Databáze: OpenAIRE
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