Lenograstim as Support for ACE Chemotherapy of Small-Cell Lung Cancer
| Autor: | N. Samaras, Peter Drings, U. Gatzemeier, R. Palisses, Gilles Robinet, Felipe Cardenal, R. J. Snijder, J.P. Kleisbauer, M. J. Melo, J. von Pawel, E. Kaukel |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Lung Neoplasms Cyclophosphamide Neutrophils medicine.medical_treatment Small-cell carcinoma Gastroenterology Lenograstim Leukocyte Count chemistry.chemical_compound Adjuvants Immunologic Internal medicine Antineoplastic Combined Chemotherapy Protocols Granulocyte Colony-Stimulating Factor medicine Humans Carcinoma Small Cell Lung cancer Antineoplastic Agents Alkylating Etoposide Aged Chemotherapy Antibiotics Antineoplastic business.industry Remission Induction Middle Aged medicine.disease Antineoplastic Agents Phytogenic Recombinant Proteins Nitrogen mustard Surgery Survival Rate Oncology chemistry Doxorubicin Absolute neutrophil count Female business Follow-Up Studies medicine.drug |
| Zdroj: | American Journal of Clinical Oncology: Cancer Clinical Trials. 23:393-400 |
| ISSN: | 0277-3732 |
| DOI: | 10.1097/00000421-200008000-00017 |
| Popis: | This phase III study was conducted to evaluate the usefulness of lenograstim as support for ACE (doxorubicin, cyclophosphamide, and etoposide) chemotherapy in previously untreated patients with small-cell lung cancer. Patients were randomized to receive up to six 3-week cycles of either ACE alone (n = 139) or ACE with lenograstim support (150 microg/m2/day subcutaneously, days 4-13, n = 141). Compared with the chemotherapy-alone group, the lenograstim support group was more likely to achieve neutrophil recovery (absolute neutrophil count, > or =1.5 x 10(9) cells/l) by day 14 (95.8-100% vs. 14.3-24.1% across the cycles) and less likely to experience at least one infectious episode (36.7 vs. 54.0%; p = 0.004), chemotherapy delay (51.8 vs. 56.2%; NS), or dose reduction (17.3 vs. 27.7%; p = 0.037). Objective response and event-free and overall survival rates were similar. Lenograstim was well tolerated. Lenograstim may allow the interval between cycles of ACE to be reduced to 2 weeks; such dose intensification may lead to more favorable objective response and survival rates. |
| Databáze: | OpenAIRE |
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