An investig-ation into the epidemiology of chikungunya virus across neglected regions of Indonesia

Autor: R. Tedjo Sasmono, Marsha S. Santoso, Ann M. Powers, Simon D. W. Frost, Frilasita A. Yudhaputri, Benediktus Yohan, Rahma F. Hayati, Barbara Blacklaws, Samuel C B Stubbs, Dionisius Denis, Edison Johar, Khin Saw Aye Myint
Přispěvatelé: Stubbs, Samuel CB [0000-0003-4175-6464], Johar, Edison [0000-0002-9491-6487], Yohan, Benediktus [0000-0003-2378-2386], Santoso, Marsha S [0000-0002-1644-6213], Hayati, Rahma F [0000-0002-1627-9187], Denis, Dionisius [0000-0002-2911-9705], Blacklaws, Barbara A [0000-0001-5454-6496], Sasmono, R Tedjo [0000-0003-0986-2590], Myint, Khin Saw Aye [0000-0002-2087-7331], Frost, Simon DW [0000-0002-5207-9879], Apollo - University of Cambridge Repository, Stubbs, Samuel C. B. [0000-0003-4175-6464], Santoso, Marsha S. [0000-0002-1644-6213], Hayati, Rahma F. [0000-0002-1627-9187], Blacklaws, Barbara A. [0000-0001-5454-6496], Sasmono, R. Tedjo [0000-0003-0986-2590], Frost, Simon D. W. [0000-0002-5207-9879]
Rok vydání: 2020
Předmět:
0301 basic medicine
RNA viruses
FOS: Computer and information sciences
Male
Viral Diseases
RC955-962
Artificial Gene Amplification and Extension
Monkeys
medicine.disease_cause
Pathology and Laboratory Medicine
Polymerase Chain Reaction
Disease Outbreaks
Geographical Locations
0302 clinical medicine
Medical Conditions
Seroepidemiologic Studies
Arctic medicine. Tropical medicine
Epidemiology
Chikungunya
Clade
Socioeconomics
Child
Phylogeny
Data Management
Mammals
Computer and information sciences
Eukaryota
virus diseases
Phylogenetic Analysis
Middle Aged
Indonesian
Phylogenetics
Geography
Infectious Diseases
Medical Microbiology
Viral Pathogens
Child
Preschool
Viruses
Vertebrates
language
RNA
Viral
Female
Public aspects of medicine
RA1-1270
Pathogens
Chikungunya virus
Macaque
Neglected Tropical Diseases
Research Article
Primates
Adult
medicine.medical_specialty
Asia
Adolescent
Alphaviruses
030231 tropical medicine
Oceania
Microbiology
Virus
Togaviruses
03 medical and health sciences
Young Adult
Old World monkeys
medicine
Seroprevalence
Animals
Humans
Evolutionary Systematics
Molecular Biology Techniques
Microbial Pathogens
Molecular Biology
Taxonomy
Medicine and health sciences
Genetic diversity
Evolutionary Biology
Biology and life sciences
Public Health
Environmental and Occupational Health
Organisms
Outbreak
Chikungunya Infection
Infant
Reverse Transcriptase-Polymerase Chain Reaction
Tropical Diseases
language.human_language
Research and analysis methods
030104 developmental biology
Indonesia
Amniotes
Chikungunya Fever
People and places
Zoology
Zdroj: PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 14, Iss 12, p e0008934 (2020)
ISSN: 1935-2735
DOI: 10.17863/cam.59441
Popis: Funder: US-CDC
Background: Chikungunya virus (CHIKV) is an important emerging and re-emerging public health problem worldwide. In Indonesia, where the virus is endemic, epidemiological information from outside of the main islands of Java and Bali is limited. Methodology/Principal Findings: Four hundred and seventy nine acutely febrile patients presenting between September 2017–2019 were recruited from three city hospitals situated in Ambon, Maluku; Banjarmasin, Kalimantan; and Batam, Batam Island as part of a multi-site observational study. CHIKV RNA was detected in a single serum sample while a separate sample was IgM positive. IgG seroprevalence was also low across all three sites, ranging from 1.4–3.2%. The single RT-PCR positive sample from this study and 24 archived samples collected during other recent outbreaks throughout Indonesia were subjected to complete coding region sequencing to assess the genetic diversity of Indonesian strains. Phylogenetic analysis revealed all to be of a single clade, which was distinct from CHIKV strains recently reported from neighbouring regions including the Philippines and the Pacific Islands. Conclusions/Significance: Chikungunya virus strains from recent outbreaks across Indonesia all belong to a single clade. However, low-level seroprevalence and molecular detection of CHIKV across the three study sites appears to contrast with the generally high seroprevalences that have been reported for non-outbreak settings in Java and Bali, and may account for the relative lack of CHIKV epidemiological data from other regions of Indonesia.
Databáze: OpenAIRE
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