Decrease in serum dehydroepiandrosterone level after fenofibrate treatment in males with hyperlipidemia
| Autor: | Šulcová, J., Štulc, T., Hill, M., Hampl, R., Mašek, Z., Vondra, K., Richard Ceska |
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| Rok vydání: | 2005 |
| Předmět: | |
| Zdroj: | Scopus-Elsevier ResearcherID |
| ISSN: | 1802-9973 0862-8408 |
| DOI: | 10.33549/physiolres.930593 |
| Popis: | The influence of steroid hormones on plasma lipids and lipoproteins was confirmed by many studies. On the other hand, the effect of plasma lipids on metabolism of steroid hormones has so far not been examined. The objective of this research project was to determine (1) the levels of cortisol, testosterone, estradiol, dehydroepiandrosterone (DHEA), its sulfate (DHEAS), 7-hydroxylated DHEA, and SHBG in men suffering from mixed hyperlipidemia (HPL) (n=23, age 46.1+/-7.9 years) in comparison with healthy male volunteers (n=17, age 45.1+/-15.6 years); (2) whether therapy with fenofibrate influences the levels of the above mentioned steroids and SHBG; (3) what are the correlations between lipids and steroids in healthy males and HPL patients before and after therapy. Compared to controls, untreated patients had significantly higher estradiol and free testosterone index (IFT) levels (p |
| Databáze: | OpenAIRE |
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