Regadenoson pharmacologic stress for myocardial perfusion imaging: a three-way comparison between regadenoson administered at peak exercise, during walk recovery, or no-exercise
| Autor: | Timothy M. Bateman, Kevin A. Bybee, Mohammed Al-Amoodi, Randall C. Thompson, Kevin F. Kennedy, Elaine C. Thompson, Gregory S. Thomas, Harshal Patil, James H. O'Keefe, Lisa Oakes, A. Iain McGhie |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Adenosine A2 Receptor Agonists Rest Vasodilator Agents Stress testing chemical and pharmacologic phenomena Coronary Artery Disease Walking Sensitivity and Specificity law.invention Myocardial perfusion imaging Randomized controlled trial immune system diseases law hemic and lymphatic diseases Prevalence Medicine Humans Radiology Nuclear Medicine and imaging Peak exercise Tomography Emission-Computed Single-Photon medicine.diagnostic_test business.industry Myocardial Perfusion Imaging Reproducibility of Results hemic and immune systems Middle Aged Regadenoson Vasodilator agents Purines Anesthesia Exercise Test Physical Endurance Pyrazoles Female Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology. 20(2) |
| ISSN: | 1532-6551 |
| Popis: | Regadenoson (Reg) is being administered with increasing frequency either at peak exercise (ExPeak-Reg) or during a slow-down/walking recovery state (ExRec-Reg) rather than at rest (Rest-Reg). The aim of this study was to compare the clinical response of ExPeak-Reg, ExRec-Reg, and Rest-Reg.We compared 531 patients divided equally between Rest-Reg, ExPeak-Reg, and ExRec-Reg matched for age, sex, and BMI.The average systolic blood pressure (SBP) rise following Reg was modest, but there was considerable heterogeneity and the ExPeak-Reg group had a higher percentage of patients who had a SBP rise of 40 mm Hg or a fall of 20 mm Hg than either the ExRec-Reg or the Rest-Reg groups (≥40 mm Hg rise 6.8%, 1.7%, and 1.7%, respectively) (P .02) (≥20 mm Hg fall 15.8%, 13.0%, and 7.3%, respectively) (P .05). Chest discomfort, nausea, dizziness, and interfering abdominal radiotracer activity were less common in both exercise Reg groups compared to Rest-Reg (P .05).Regadenoson injected at peak of symptom-limited exercise was generally well tolerated, but some patients had a significant rise or drop in SBP. There is no apparent advantage of administering regadenoson at peak exercise rather than during walk recovery, and the latter approach may have a greater safety margin. |
| Databáze: | OpenAIRE |
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