The Nutrition, Aging, and Memory in Elders (NAME) study: design and methods for a study of micronutrients and cognitive function in a homebound elderly population
| Autor: | Katherine L. Tucker, Lauren Smaldone, Mark J. Sarnak, Wei Qiao Qiu, Lori Lyn Price, Irwin H. Rosenberg, Jacqueline Yee, Jose M. Ordovas, Marshal F. Folstein, Daniel E. Weiner, Lauren Collins, Inga Peter, Lixia Wang, Samuel Patz, Jennifer S. Buell, Drew Leins, John L. Griffith, Rafeeque A. Bhadelia, Carey Wagner, Timothy Liu, Peter R. Bergethon, John F. Dashe, Patricia L. Hibberd, Lisa Arsenault, Jacob Selhub, Tammy Scott |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Research design Gerontology Aging medicine.medical_specialty Activities of daily living Population Neuropsychological Tests Homebound Persons Quality of life (healthcare) Activities of Daily Living medicine Humans Dementia Nutritional Physiological Phenomena Micronutrients education Geriatric Assessment Aged Aged 80 and over Geriatrics education.field_of_study business.industry Brain Cognition Middle Aged medicine.disease Magnetic Resonance Imaging Psychiatry and Mental health Research Design Female Geriatrics and Gerontology Cognition Disorders business |
| Zdroj: | International Journal of Geriatric Psychiatry. 21:519-528 |
| ISSN: | 1099-1166 0885-6230 |
| DOI: | 10.1002/gps.1503 |
| Popis: | Background Micronutrient status can affect cognitive function in the elderly; however, there is much to learn about the precise effects. Understanding mediating factors by which micronutrient status affects cognitive function would contribute to elders' quality of life and their ability to remain in the home. Objectives The Nutrition, Aging, and Memory in Elders (NAME) Study is designed to advance the current level of knowledge by investigating potential mediating factors by which micronutrient status contributes to cognitive impairment and central nervous system abnormalities in the elderly. NAME targets homebound elders because they are understudied and particularly at risk for poor nutritional status. Methods Subjects are community-based elders aged 60 and older, recruited through area Aging Services Access Points. The NAME core data include demographics; neuropsychological testing and activities of daily living measures; food frequency, health and behavioral questionnaires; anthropometrics; gene status; plasma micronutrients, homocysteine, and other blood determinants. A neurological examination, psychiatric examination, and brain MRI and volumetric measurements are obtained from a sub-sample. Results Preliminary data from first 300 subjects are reported. These data show that the NAME protocol is feasible and that the enrolled subjects are racially diverse, at-risk, and had similar basic demographics to the population from which they were drawn. Conclusion The goal of the NAME study is to evaluate novel relationships between nutritional factors and cognitive impairment. These data may provide important information on potential new therapeutic strategies and supplementation standards for the elderly to maintain cognitive function and potentially reduce the public health costs of dementia. Copyright © 2006 John Wiley & Sons, Ltd. |
| Databáze: | OpenAIRE |
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