Apolipoprotein E Alleles in Cuban Patients With Mild Cognitive Impairment
| Autor: | Maria A. Bobes, David Higginson Clarke, Ana María Riverón, Elena del Carmen Ruiz López, Viana Manrique Suárez, Yuriem Fernandez, Lilia López-Cánovas |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Apolipoprotein E medicine.medical_specialty Apolipoprotein E4 Amnesia Apolipoproteins E Gene Frequency Internal medicine Epidemiology medicine Humans Dementia Cognitive Dysfunction Allele Risk factor Psychiatry Allele frequency Alleles Aged Aged 80 and over General Neuroscience Cuba Cognition medicine.disease Psychiatry and Mental health Clinical Psychology Female Geriatrics and Gerontology medicine.symptom Psychology |
| Zdroj: | American Journal of Alzheimer's Disease & Other Dementiasr. 29:236-241 |
| ISSN: | 1938-2731 1533-3175 |
| DOI: | 10.1177/1533317513517037 |
| Popis: | Background: Apolipoprotein E (ApoE) ∊4 genotype is the most clearly documented risk factor for Alzheimer’s disease (AD). Epidemiological studies demonstrate an accelerated rate of progression to dementia and AD in patients with mild cognitive impairment (MCI). We assessed the ApoE allele and genotypes frequencies in Cuban patients with MCI. Methods: We performed ApoE genotyping of 74 Cuban patients more than 65 years old. Cognitive assessments included the Mini-Mental State Examination (MMSE) and a cognitive battery for evaluating memory, attention, perception, and executive function. Results: Cognitive impairments were characterized by amnesia and executive deficits in patients with MCI. The Apo ∊4 allele frequency was 0.196 in patients with MCI, 10-fold higher than that in the controls. Patients carrying the ∊4 allele exhibited poorer performance in MMSE and tests assessing executive function and short-term memory than noncarriers. Conclusions: The patients exhibited amnestic MCI multiple domains. Cognitive performance was worse in patients who carried the ApoE ∊4 allele. |
| Databáze: | OpenAIRE |
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