Etiologic, Clinical, and Pathologic Analysis of 31 Fatal Cases of Acute Respiratory Tract Infection in Argentinian Children Under 5 Years of Age
| Autor: | Patricia Murtagh, Mercedes Weissenbacher, Mariana Catalano, Doracio Salomón, María M. Avila, Mónica Siminovich, M. Cristina Cerqueiro, Guadalupe Carballal |
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| Rok vydání: | 1990 |
| Předmět: |
Heart Defects
Congenital Male Microbiology (medical) medicine.medical_specialty Pediatrics Argentina Necrotizing bronchiolitis Autopsy Gastroenterology Internal medicine Case fatality rate medicine Humans Lung Respiratory Tract Infections Acute respiratory tract infection Respiratory tract infections business.industry Respiratory disease Age Factors Infant Newborn Infant Bacterial Infections Pneumonia medicine.disease Nutrition Disorders Infectious Diseases Virus Diseases Bronchiolitis Child Preschool Acute Disease Female business Infant Premature |
| Zdroj: | Clinical Infectious Diseases. 12:S1074-S1080 |
| ISSN: | 1537-6591 1058-4838 |
| DOI: | 10.1093/clinids/12.supplement_8.s1074 |
| Popis: | During a 3-year survey of 805 children with acute lower respiratory tract infection (ALRI) who were admitted to three hospitals in Buenos Aires, 31 fatal cases were recorded--a fatality rate of 3.8%. Of the 31 children who died, 77% were less than 1 year of age, 48% were boys, 58% were malnourished, 29% had previous respiratory disease, and 22% had previous congenital disease. All children who died had clinical diagnoses of pneumonia (71%) or bronchiolitis (29%). Autopsies were performed in 14 of the cases. Viral etiology was determined by both cell culture and indirect immunofluorescence (IIF) assay of either nasopharyngeal aspirates (NPA) or lung tissue and bacterial etiology was determined by isolation of organisms from blood, lung tissue, and/or pleural fluid. NPA was examined for Bordetella pertussis by IIF. Pathogens were identified in 65% of fatal cases. Seven cases were bacterial; seven cases were viral; and six cases resulted from mixed infections. Lung tissue yielded positive etiologic results in 10 of 13 cases. Histopathologic examination performed on specimens from the 14 autopsied children revealed necrotizing bronchiolitis with intranuclear inclusions (n = 5) and multifocal pneumonia (n = 9). |
| Databáze: | OpenAIRE |
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