Ultrastructural Identification of Exocytosis of Granules from Human Gut Eosinophils in vivo
| Autor: | Rita A. Monahan-Earley, Andrew B. Onderdonk, William Silen, Ellen S. Morgan, Ronald L. Cisneros, J E Blair, J. B. Cullen, Linda Letourneau, Ann M. Dvorak, Zane Cohen, Donald A. Antonioli, Robin S. McLeod |
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| Rok vydání: | 1993 |
| Předmět: |
Pathology
medicine.medical_specialty Gastrointestinal Diseases Cell Degranulation Biopsy Staphylococcus Immunology Biology Cytoplasmic Granules Exocytosis In vivo medicine Humans Immunology and Allergy Secretion medicine.diagnostic_test Eosinophil Granule Proteins General Medicine Eosinophil medicine.disease Ulcerative colitis Axons Eosinophils Intestines medicine.anatomical_structure Toxicity |
| Zdroj: | International Archives of Allergy and Immunology. 102:33-45 |
| ISSN: | 1423-0097 1018-2438 |
| DOI: | 10.1159/000236548 |
| Popis: | Twenty-two percent of 117 biopsies of human intestinal tissues had ultrastructural images of classical regulated secretion from eosinophils in vivo i.e. eosinophil granule extrusion (EGE). Replicate intestinal biopsies that were positive for bacteria had EGE more often than not (p < 0.05); 77% of the isolates were Staphylococci. Some of the intestinal biopsies also had damaged nerves; all that had EGE and damaged enteric nerves also had positive bacterial cultures. The EGE that we observed could not account for all enteric nerve damage, suggesting multifactorial mechanisms for nerve damage in gut tissues. Among the possibilities are release of neurotoxic eosinophil granule proteins by an alternate secretory route, i.e., piecemeal degranulation, direct toxicity of tissue invasive bacteria and/or damaged nerves of unknown etiology such as those that are regularly present in uninvolved tissues of patients with Crohn's disease. |
| Databáze: | OpenAIRE |
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