Directional Notch trafficking in Sara endosomes during asymmetric cell division in the spinal cord

Autor: Sabine Kressmann, Marcos González-Gaitán, Maximilian Fürthauer, Claudia Guimarães Camargo Campos, Irinka Castanon
Přispěvatelé: Institut de Biologie Valrose (IBV), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)
Jazyk: angličtina
Rok vydání: 2015
Předmět:
MESH: Neural Stem Cells
MESH: Signal Transduction
Embryo
Nonmammalian
Cell division
Cellular differentiation
MESH: Neurons
MESH: Spinal Cord
0302 clinical medicine
Neural Stem Cells
Cell Movement
MESH: Gene Expression Regulation
Developmental
Asymmetric cell division
MESH: Animals
MESH: Nerve Tissue Proteins
MESH: Cell Movement
[SDV.BDD]Life Sciences [q-bio]/Development Biology
Zebrafish
Neurons
0303 health sciences
Receptors
Notch
Neurogenesis
Gene Expression Regulation
Developmental
Cell Differentiation
Neural stem cell
Endocytosis
Cell biology
Protein Transport
Spinal Cord
ddc:540
MESH: Endocytosis
Signal Transduction
MESH: Cell Differentiation
MESH: Protein Transport
Endosome
MESH: Asymmetric Cell Division
Nerve Tissue Proteins
MESH: Zebrafish Proteins
MESH: Carrier Proteins
Endosomes
Biology
Cell fate determination
03 medical and health sciences
Animals
Cell Lineage
MESH: Zebrafish
Mitosis
030304 developmental biology
Asymmetric Cell Division
MESH: Embryo
Nonmammalian
Cell Biology
Zebrafish Proteins
MESH: Cell Lineage
MESH: Neurogenesis
MESH: Endosomes
Carrier Proteins
MESH: Receptors
Notch
030217 neurology & neurosurgery
Zdroj: Nature Cell Biology
Nature Cell Biology, Nature Publishing Group, 2015, 17 (3), pp.333-9
Nature cell biology
Nature Cell Biology, Vol. 17, No 3 (2015) pp. 333-339
ISSN: 1465-7392
1476-4679
Popis: International audience; Asymmetric division of neural precursor cells contributes to the generation of a variety of neuronal types. Asymmetric division is mediated by the asymmetric inheritance of fate determinants by the two daughter cells. In vertebrates, asymmetric fate determinants, such as Par3 and Mib, are only now starting to be identified. Here we show that, during mitosis of neural precursors in zebrafish, directional trafficking of Sara endosomes to one of the daughters can function as such a determinant. In asymmetric lineages, where one daughter cell becomes a neuron (n cell) whereas the other divides again to give rise to two neurons (p cell), we found that the daughter that inherits most of the Sara endosomes acquires the p fate. Sara endosomes carry an endocytosed pool of the Notch ligand DeltaD, which is thereby itself distributed asymmetrically. Sara and Notch are both essential for cell fate assignation within asymmetric lineages. Therefore, the Sara endosome system determines the fate decision between neuronal differentiation and mitosis in asymmetric lineages and thereby contributes to controlling the number of neural precursors and differentiated neurons during neurogenesis in a vertebrate.
Databáze: OpenAIRE
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