Peripheral Tissue Homing Receptors Enable T Cell Entry into Lymph Nodes and Affect the Anatomical Distribution of Memory Cells
| Autor: | Sherin J. Rouhani, Nithya Srinivasan, Victor H. Engelhard, C. Colin Brinkman |
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| Rok vydání: | 2013 |
| Předmět: |
Adoptive cell transfer
Effector T cell Immunology CD8-Positive T-Lymphocytes Biology Adoptive Transfer Article Cell biology Mice Inbred C57BL Chemotaxis Leukocyte Mice medicine.anatomical_structure medicine Animals Immunology and Allergy Cytotoxic T cell Lymph Nodes Lymph Antigen-presenting cell Immunologic Memory CD8 Homing (hematopoietic) |
| Zdroj: | The Journal of Immunology. 191:2412-2425 |
| ISSN: | 1550-6606 0022-1767 |
| Popis: | Peripheral tissue homing receptors enable T cells to access inflamed nonlymphoid tissues. In this study, we show that two such molecules, E-selectin ligand and α4β1 integrin, enable activated and memory T cells to enter lymph nodes (LN) as well. This affects the quantitative and qualitative distribution of these cells among regional LN beds. CD8 memory T cells in LN that express these molecules were mostly CD62Llo and would normally be classified as effector memory cells. However, similar to central memory cells, they expanded upon Ag re-encounter. This led to differences in the magnitude of the recall response that depended on the route of immunization. These novel cells share properties of both central and effector memory cells and reside in LN based on previously undescribed mechanisms of entry. |
| Databáze: | OpenAIRE |
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