Serum human placental lactogen and prolactin may not be associated with aberrant glucose homeostasis in GDM
| Autor: | Mashfiqul Hasan, Sharmin Jahan, Muhammad Abul Hasanat, Mahmudul Hossain, Mohammad Farid Uddin, Mohammad Fakhrul Alam, Nusrat Sultana |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
prolactin
medicine.medical_specialty homa-ir endocrine system diseases human placental lactogen Diseases of the endocrine glands. Clinical endocrinology Pathogenesis Human placental lactogen Insulin resistance Internal medicine medicine Glucose homeostasis General Environmental Science gdm business.industry homa-b nutritional and metabolic diseases RC648-665 medicine.disease Prolactin Gestational diabetes Endocrinology Homeostatic model assessment General Earth and Planetary Sciences Gestation business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Journal of Diabetology, Vol 12, Iss 5, Pp 66-72 (2021) |
| ISSN: | 2078-7685 |
| DOI: | 10.4103/jod.jod_111_20 |
| Popis: | Background: Gestational diabetes mellitus (GDM) shows insufficient β-cell compensation for insulin resistance (IR) during late pregnancy, whereupon derangements of human placental lactogen (hPL) and prolactin (PRL) have a presumed role in its pathogenesis. Aims: To assess the relationship of serum hPL and PRL with IR and β-cell function in GDM and pregnant women with normal glucose tolerance (NGT). Materials and Methods: This cross-sectional study was performed with 40 women with GDM and an equal number of pregnant women with NGT who were diagnosed on the basis of the WHO 2013 criteria during 24–40 weeks of gestation. hPL was measured by an enzyme-linked immunosorbent assay (ELISA); PRL and fasting insulin were measured by a chemiluminescent immunoassay. Equations of homeostatic model assessment (HOMA) were used to calculate the indices of IR (HOMA-IR) and β-cell function (HOMA-B). Results: No statistically significant difference was found between the GDM and NGT groups in circulating concentrations of either hPL (6.01 ± 1.76 vs. 5.92 ± 2.10 mg/L, mean ± SD; P = 0.852) or PR [180.27 (125.95–306.20) vs. 166.87 (134.24–284.70) ng/mL, median (IQR); P = 0.704]. There was no relationship of circulatory levels of hPL and PRL with glucose values at different time points during oral glucose tolerance test as well as with AUCglucose (P = NS for all). On multiple regression analysis, neither hPL nor PRL emerged as a significant predictor for fasting insulin, HOMA-IR, and HOMA-B in GDM (P = NS for all). Conclusions: Circulating concentration of hPL and PRL may not be a potential determinant of IR and β-cell dysfunction in GDM. |
| Databáze: | OpenAIRE |
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