Association of CD4+ T-cell Count, HIV-1 RNA Viral Load, and Antiretroviral Therapy With Kaposi Sarcoma Risk Among HIV-infected Persons in the United States and Canada
| Autor: | Chad J Achenbach, Gypsyamber DʼSouza, Sharada P. Modur, Timothy R. Sterling, Richard M Novak, Surbhi Grover, Amy C. Justice, Angel M. Mayor, Romain Neugebauer, Richard D. Moore, Wendy A. Leyden, Mari M. Kitahata, Robert Dubrow, Nancy A. Hessol, Michael A. Horberg, Charles S. Rabkin, Li Qin, Eric A. Engels, Michael J. Silverberg, Raúl U. Hernández-Ramírez, Haiqun Lin, Ronald J. Bosch, James J. Goedert, Keri N. Althoff |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
CD4-Positive T-Lymphocytes Male Oncology Canada medicine.medical_specialty Anti-HIV Agents HIV Infections Article Cohort Studies 03 medical and health sciences 0302 clinical medicine Acquired immunodeficiency syndrome (AIDS) Internal medicine medicine Humans Pharmacology (medical) 030212 general & internal medicine Sarcoma Kaposi Proportional Hazards Models business.industry Proportional hazards model Middle Aged Viral Load medicine.disease Antiretroviral therapy United States CD4 Lymphocyte Count Infectious Diseases 030220 oncology & carcinogenesis Cohort Immunology Etiology RNA Viral Female Sarcoma business Viral load Cohort study |
| Zdroj: | JAIDS Journal of Acquired Immune Deficiency Syndromes. 75:382-390 |
| ISSN: | 1525-4135 |
| Popis: | Kaposi sarcoma (KS) remains common among HIV-infected persons. To better understand KS etiology and to help target prevention efforts, we comprehensively examined a variety of CD4 T-cell count and HIV-1 RNA viral load (VL) measures, as well as antiretroviral therapy (ART) use, to determine independent predictors of KS risk.North American AIDS Cohort Collaboration on Research and Design.We followed HIV-infected persons during 1996-2009 from 18 cohorts. We used time-updated Cox regression to model relationships between KS risk and recent, lagged, trajectory, and cumulative CD4 count or VL measures, as well as ART use. We used Akaike's information criterion and global P values to derive a final model.In separate models, the relationship between each measure and KS risk was highly significant (P0.0001). Our final mutually adjusted model included recent CD4 count [hazard ratio (HR) for50 vs. ≥500 cells/μL = 12.4; 95% confidence interval (CI): 6.5 to 23.8], recent VL (HR for ≥100,000 vs. ≤500 copies/mL = 3.8; 95% CI: 2.0 to 7.3), and cumulative (time-weighted mean) VL (HR for ≥100,000 vs. ≤500 copies/mL = 2.5; 95% CI: 1.0 to 5.9). Each P-trend was0.0001. After adjusting for these measures, we did not detect an independent association between ART use and KS risk.Our results suggested a multifactorial etiology for KS, with early and late phases of development. The cumulative VL effect suggested that controlling HIV replication promptly after HIV diagnosis is important for KS prevention. We observed no evidence for direct anti-KS activity of ART, independent of CD4 count and VL. |
| Databáze: | OpenAIRE |
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