Asymptomatic toddlers with house dust mite sensitization at risk of asthma and abnormal lung functions at age 7 years
| Autor: | Tsung-Chieh Yao, Kuan-Wen Su, Kuo-Wei Yeh, Li-Chen Chen, Jing-Long Huang, Man-Chin Hua, Ming-Han Tsai, Sui-Lin Liao, Chih-Yung Chiu |
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| Rok vydání: | 2019 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
Pulmonary and Respiratory Medicine Allergy medicine.medical_specialty Pulmonary function ISAAC International Study of Asthma and Allergies in Childhood Immunology ATS American Thoracic Society FeNO Fractional exhaled nitric oxide Asymptomatic Article Pulmonary function testing House dust mite 03 medical and health sciences FEV1 Forced expiratory volume in the first second PC20 Provocative concentrations causing a 20% fall in forced expiratory volume in the first second 0302 clinical medicine Internal medicine medicine Immunology and Allergy PATCH Prediction of Allergies in Taiwanese Children HDM House dust mite 030223 otorhinolaryngology Sensitization Asthma biology Pediatric asthma CI Confidence interval business.industry IQR Interquartile range Atopic dermatitis biology.organism_classification medicine.disease ERS European Respiratory Society IgE Immunoglobulin E medicine.anatomical_structure 030228 respiratory system FVC Forced vital capacity Exhaled nitric oxide medicine.symptom lcsh:RC581-607 business Birth cohort OR Odds ratio |
| Zdroj: | The World Allergy Organization Journal World Allergy Organization Journal, Vol 12, Iss 9, Pp-(2019) |
| ISSN: | 1939-4551 |
| DOI: | 10.1016/j.waojou.2019.100056 |
| Popis: | Objective: To evaluate the predictive value of asymptomatic early house dust mite sensitization on allergic outcomes and pulmonary functions in 7-year olds. Study design: The Prediction of Allergies in Taiwanese Children (PATCH) birth cohort study recruited healthy newborns at birth. At age 1.5–2 years, a Dermatophagoides pteronyssinus-specific immunoglobulin E level ≥ 0.35 kU/L was defined as early sensitization. At age 7 years, allergic outcomes were evaluated by pediatric allergists and pulmonologists, and fractional exhaled nitric oxide and pulmonary functions were measured. Results: At age 1.5–2 years, 28.0% of toddlers were sensitized to D. pteronyssinus. Among them, 68.2% had no allergic symptoms at that time. At age 7 years, the children with early sensitization had higher risks of asthma (OR = 13.4, 95% CI, 1.2 to 153.0; P = 0.037), allergic rhinitis (OR = 10.2, 95% CI, 2.1 to 49.6; P = 0.004), and atopic dermatitis (OR = 38.5, 95% CI, 2.1 to 696.4; P = 0.014). Notably, even the asymptomatic toddlers with early D. pteronyssinus sensitization had higher probabilities of asthma (12.5% vs. 1.7%, P = 0.040), allergic rhinitis (83.3% vs. 43.1%, P = 0.009), and atopic dermatitis (20.8% vs. 0.0%, P |
| Databáze: | OpenAIRE |
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