Oxazolidinones as novel human CCR8 antagonists

Autor:	Victoria J. Barrett, Feng Wang, Christopher Browning, Matthew J Lindon, Henry M. Sarau, James A. Fornwald, Andy J. Harker, Guido Hartmann, Jeffery K. Kerns, David P. Andrew, Graeme Irvine Stevenson, Ashley Paul Hancock, Victoria Vinader, Michael L. Moore, James J. Foley, Jian Jin, Parvathi Rao, Anthony J. Jurewicz, Helen E. Connor, Dwight M. Morrow, Kristen E. Belmonte, Yonghui Wang, Ralph A. Rivero, Cuc Nguyen
Rok vydání:	2007
Předmět:	ERG1 Potassium Channel Stereochemistry High-throughput screening Clinical Biochemistry Drug Evaluation Preclinical Human immunodeficiency virus (HIV) Pharmaceutical Science CHO Cells Computational biology Protein Serine-Threonine Kinases medicine.disease_cause Biochemistry Chemical synthesis Myotonin-Protein Kinase Receptors CCR8 Structure-Activity Relationship Cricetulus Th2 Cells Cricetinae Drug Discovery medicine Animals Humans Structure–activity relationship Computer Simulation Molecular Biology Oxazolidinones Chemistry Organic Chemistry Ether-A-Go-Go Potassium Channels Chemotaxis Leukocyte Lung disease Molecular Medicine Indicators and Reagents Receptors Chemokine
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 17:1722-1725
ISSN:	0960-894X
DOI:	10.1016/j.bmcl.2006.12.076
Popis:	High-throughput screening of the corporate compound collection led to the discovery of a novel series of N-substituted-5-aryl-oxazolidinones as potent human CCR8 antagonists. The synthesis, structure-activity relationships, and optimization of the series that led to the identification of SB-649701 (1a), are described.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33f387c8ba0cdb9889dd18456ec30b9e https://doi.org/10.1016/j.bmcl.2006.12.076 Zobrazit plný text záznamu Full Text from ScienceDirect