Macromolecular iron-chelators via RAFT-polymerization for the inhibition of methicillin-resistant Staphylococcus aureus growth
| Autor: | Robert C. Hider, Tao Zhou, Xiaole Kong, Junpei Li, Guoqing Zhang, Vincenzo Abbate, Selwa Alsam, Yongmin Ma, Jagoda Jurach, Osamah Al Rugaie, Eniola Olaleye |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
chemistry.chemical_classification Glycidyl methacrylate Materials science Polymers and Plastics 030106 microbiology Organic Chemistry Polymer Conjugated system 010402 general chemistry Antimicrobial medicine.disease_cause 01 natural sciences Combinatorial chemistry 0104 chemical sciences 03 medical and health sciences chemistry.chemical_compound chemistry Staphylococcus aureus Materials Chemistry medicine Organic chemistry Reversible addition−fragmentation chain-transfer polymerization Chelation Macromolecule |
| Zdroj: | Li, J, Olaleye, E, Kong, X, Zhou, T, Ma, Y, Jurach, J, Al Rugaie, O, Hider, R C, Zhang, G, Alsam, S & Abbate, V 2016, ' Macromolecular iron-chelators via RAFT-polymerization for the inhibition of methicillin-resistant Staphylococcus aureus growth ', Polymer, vol. 87, pp. 64-72 . https://doi.org/10.1016/j.polymer.2016.01.073 |
| DOI: | 10.1016/j.polymer.2016.01.073 |
| Popis: | A series of linear poly (glycidyl methacrylate) (PGMA) polymers were synthesized via RAFT polymerization and conjugated with amine-containing 3-hydroxypyridin-4-ones (HPOs) to generate a panel of HPO-containing materials with controlled structures and specific iron-binding functions. The structures of the resulting polymers were characterized via 1H NMR, GPC and FT-IR and their chelating capacity for iron was investigated using UV–Vis spectrophotometric titration of the iron(III) complexes. In vitro antimicrobial studies of selected ligand-containing homopolymers demonstrate that the homopolymers are capable of inhibiting the growth of methicillin-resistant Staphylococcus aureus (MRSA). It is proposed that the inhibition activity of MRSA is derived from the iron-chelating capability of the iron-binding polymers. |
| Databáze: | OpenAIRE |
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