[Circulating citrulline levels: a biomarker for intestinal functionality assessment]
| Autor: | Nathalie Neveux, Mouna Hanachi, Pascal Crenn, Luc Cynober |
|---|---|
| Přispěvatelé: | Groupe de Recherche Clinique et Technologique sur le Handicap ( GRCTH ), Université de Versailles Saint-Quentin-en-Yvelines ( UVSQ ), AP-HP Hôpital Raymond Poincaré [Garches], Prévention et traitement de la perte protéique musculaire en situation de résistance à l'anabolisme ( PRETRRAM - EA 4466 ), Université Paris Descartes - Paris 5 ( UPD5 ), Service de biochimie et de génétique moléculaire [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Cochin [AP-HP], Crenn, Pascal, Groupe de Recherche Clinique et Technologique sur le Handicap (GRCTH), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Hôpital Raymond Poincaré [AP-HP], Prévention et traitement de la perte protéique musculaire en situation de résistance à l'anabolisme (PRETRRAM - EA 4466), Université Paris Descartes - Paris 5 (UPD5), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP) |
| Jazyk: | francouzština |
| Rok vydání: | 2011 |
| Předmět: |
Arginine
030309 nutrition & dietetics medicine.medical_treatment [ SDV.AEN ] Life Sciences [q-bio]/Food and Nutrition MESH : Models Biological MESH: Intestinal Diseases Gastroenterology Severity of Illness Index MESH : Nutritional Status chemistry.chemical_compound 0302 clinical medicine [ SDV.BBM.BC ] Life Sciences [q-bio]/Biochemistry Molecular Biology/Biomolecules [q-bio.BM] Citrulline insuffisance intestinale [SDV.BBM.BC] Life Sciences [q-bio]/Biochemistry Molecular Biology/Biochemistry [q-bio.BM] 2. Zero hunger MESH : Intestines 0303 health sciences Kidney General Medicine MESH : Intestinal Diseases MESH: Nutritional Status 3. Good health Intestines medicine.anatomical_structure 030220 oncology & carcinogenesis Urea cycle Biomarker (medicine) MESH : Severity of Illness Index [ SDV.MHEP.HEG ] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology MESH: Intestines medicine.medical_specialty Enterocyte Nutritional Status Biology Models Biological entérocyte 03 medical and health sciences intestin Internal medicine MESH: Severity of Illness Index medicine Humans [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry Molecular Biology/Biochemistry [q-bio.BM] MESH: Clinical Laboratory Techniques Chemotherapy MESH: Humans Clinical Laboratory Techniques Citrullinemia MESH : Humans MESH: Biological Markers MESH: Models Biological MESH : Citrulline [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology MESH : Clinical Laboratory Techniques medicine.disease [SDV.MHEP.HEG] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology MESH : Biological Markers Intestinal Diseases [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition Endocrinology chemistry citrulline MESH: Citrulline [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition Biomarkers |
| Zdroj: | Annales de Biologie Clinique Annales de Biologie Clinique, John Libbey Eurotext, 2011, 69 (5), pp.513-21. 〈10.1684/abc.2011.0609〉 Annales de Biologie Clinique, John Libbey Eurotext, 2011, 69 (5), pp.513-21. ⟨10.1684/abc.2011.0609⟩ |
| ISSN: | 0003-3898 |
| DOI: | 10.1684/abc.2011.0609〉 |
| Popis: | International audience; Circulating citrulline is emerging as an innovating biomarker candidate for assessment of intestinal function. Amino acid synthesized by enterocytes of intestinal mucosal, citrulline is not included in proteins or nutrition products and is a precursor for production of arginine by the kidney. Plasma citrulline is, in clinical situation, an established biomarker of enterocyte functional metabolic mass (trophicity) in children and in adult patients due to its high relation to active functional small bowel remnant length in intestinal diseases (short bowel, extensive enteropathies, intestinal toxicity of chemotherapy and radiotherapy. Plasma citrulline concentration (30-50 μmol/L), independent of nutritional status, if less than 10 μmol/L can give an objective threshold for nutrition parenteral use in case of intestinal failure due to enterocyte abnormalities or lack. Its regular dosage allows the monitoring of intestinal function except in case of significant renal failure. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|