21.1.1, A novel activation marker of T and B cells
| Autor: | Wolf H. Fridman, Marc Daëron, Marie-Anne Cousin, Danielle Lando, Brigitte Bauvois, Véronique Malard, Sebastian Amigorena, Catherine Sautes |
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| Rok vydání: | 1991 |
| Předmět: |
Antigens
Differentiation T-Lymphocyte Time Factors T-Lymphocytes T cell Immunology CD1 Thymus Gland Biology Lymphocyte Activation Mice medicine Animals Cytotoxic T cell Isoelectric Point IL-2 receptor Antigen-presenting cell Molecular Biology B-Lymphocytes CD40 Antibodies Monoclonal Flow Cytometry Molecular biology Antigens Differentiation B-Lymphocyte Molecular Weight B-1 cell Thymocyte medicine.anatomical_structure biology.protein Spleen |
| Zdroj: | Molecular Immunology. 28:417-426 |
| ISSN: | 0161-5890 |
| DOI: | 10.1016/0161-5890(91)90155-d |
| Popis: | A new rat mAb designated mAb 21.1.1 was raised against a T cell hybridoma of mouse origin, T2D4. This antibody, an IgG2b, immunoprecipitates from the membrane extracts of iodinated T2D4 cells a 56-kDa glycoprotein of apparent pI 4.6 which gives a 34-kDa polypeptide after treatment with endoglycosidase F. MAb 21.1.1 reacts with an antigen expressed on murine mitogen-activated thymocytes and T cells, and on B cells stimulated by anti-IgM antibodies. Cells isolated from the spleen, lymph nodes and bone marrow are negative, as are purified resting B cells or T cells. This antigen is strongly expressed on most day-16 fetal thymocytes whereas adult thymocytes are almost negative. mAb 21.1.1 may be useful for the study of activation and differentiation of T and B cells. |
| Databáze: | OpenAIRE |
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