Cardiovascular magnetic resonance stress and rest T1-mapping using regadenoson for detection of ischemic heart disease compared to healthy controls

Autor: Matthew K. Burrage, Stefan Neubauer, Vanessa M Ferreira, Stefan K. Piechnik, Ambra Masi, Joana Leal Pelado, Evan Hann, Mayooran Shanmuganathan, Rajkumar Soundarajan, Iulia A. Popescu, Kelvin Chow, Qiang Zhang
Rok vydání: 2021
Předmět:
medicine.medical_specialty
Magnetic Resonance Spectroscopy
Myocardial Ischemia
Contrast Media
Magnetic Resonance Imaging
Cine
T1-mapping
Coronary Artery Disease
Disease
030204 cardiovascular system & hematology
Regadenoson
Article
Coronary artery disease
03 medical and health sciences
0302 clinical medicine
Predictive Value of Tests
Coronary Circulation
Internal medicine
Humans
Medicine
cardiovascular diseases
030212 general & internal medicine
Rest (music)
medicine.diagnostic_test
business.industry
Myocardium
Myocardial Perfusion Imaging
Magnetic resonance imaging
medicine.disease
Magnetic Resonance Imaging
Adenosine
Perfusion
Purines
Cardiology
ShMOLLI
Pyrazoles
Cardiovascular magnetic resonance
Coronary vasodilator
Cardiology and Cardiovascular Medicine
business
Ischemic heart
medicine.drug
Zdroj: International Journal of Cardiology
ISSN: 0167-5273
Popis: Background Adenosine stress T1-mapping on cardiovascular magnetic resonance (CMR) can differentiate between normal, ischemic, infarcted, and remote myocardial tissue classes without the need for contrast agents. Regadenoson, a selective coronary vasodilator, is often used in stress perfusion imaging when adenosine is contra-indicated, and has advantages in ease of administration, safety profile, and clinical workflow. We aimed to characterize the regadenoson stress T1-mapping response in healthy individuals, and to investigate its ability to differentiate between myocardial tissue classes in patients with coronary artery disease (CAD). Methods Eleven healthy controls and 25 patients with CAD underwent regadenoson stress perfusion CMR, as well as rest and stress ShMOLLI T1-mapping. Native T1 values and stress T1 reactivity were derived for normal myocardium in healthy controls and for different myocardial tissue classes in patients with CAD. Results Healthy controls had normal myocardial native T1 values at rest (931 ± 22 ms) with significant global regadenoson stress T1 reactivity (δT1 = 8.2 ± 0.8% relative to baseline; p
Highlights • Regadenoson has advantages over adenosine in terms of administration, safety profile, and clinical workflow. • There are distinct tissue characteristics for normal, ischemic, infarcted, and remote myocardium. • Healthy controls demonstrate significant stress T1 reactivity during vasodilator stress. • Regadenoson stress T1-mapping can distinguish between different myocardial tissue classes. • Regadenoson stress T1-mapping is a viable alternative to adenosine and exercise for the assessment of coronary artery disease.
Databáze: OpenAIRE
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